Wednesday March 20, 2019

Alzheimer’s disease linked to several unsaturated fatty acids in the brain: Study

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Cognitive Impairment
Alzheimer's disease patient Isidora Tomaz, 82, sits in an armchair in her house in Lisbon, Portugal. It’s predicted that by 2050, 135 million Americans are going to suffer from mild cognitive impairment, a precursor of Alzheimer's. VOA

London, March 23, 2017: Researchers have found that several unsaturated fatty acids in the brain may be associated with the progression of Alzheimer’s disease.

Alzheimer’s disease is a neurodegenerative disorder, which causes impaired memory, executive function and language. It accounts for 60-80 per cent of total dementia cases worldwide, with over 46 million people suffering from the disease worldwide. The number of patients is estimated to rise to 131.5 million by 2050.

Currently, it is thought that the main reason for developing memory problems in dementia is the presence of two big molecules in the brain called tau and amyloid proteins — that are shown to start accumulating in the brain up to 20 years prior to the onset of the disease.

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However, the findings, published in the journal PLOS Medicine, showed that the metabolism of omega-3 and omega-6 unsaturated fatty acids were significantly decreased in Alzheimer’s brains when compared to brains from healthy patients.

“Our results show a potentially crucial and unexpected role for fats in the onset of dementia. Most surprisingly, we found that a supposedly beneficial omega-3, DHA, actually increased with the progression of the disease,” said Cristina Legido Quigley from King’s College London.

In the study, the team looked at brain tissue samples from 43 people ranging in age from 57 to 95 years old.

The researchers then measured the metabolite levels of the brain regions that are commonly associated with neurodegerative diseases — the middle frontal gyrus and the inferior temporal gyrus — as well as the metabolite levels in a brain area that is not normally affected by the disease’s pathology — the cerebellum.

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The results showed that unsaturated fatty acid metabolism is significantly dysregulated in the brains of patients with varying degrees of Alzheimer pathology.

The main molecules that were different were six small fats — docosahexaenoic acid, linoleic acid, arachidonic acid, linolenic acid, eicosapentaenoic acid, and oleic acid — including omegas, which changed in abundance in different regions of the brain. (IANS)

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Intake Of Vitamin B Nutrient Can Prevent Babies From Brain Disorders Caused By Cold During Pregnancy

Cold and flu are often unavoidable, even if the mother has had a flu shot. But cold and flu during pregnancy double the risk of future mental illnesses.

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baby
When mothers had a cold or flu during the first 16 weeks of pregnancy, the newborns'  ability to cease or delay the effect on the brain decreased by 27 per cent. Pixabay

Besides flu vaccines, maternal intake of a vitamin B nutrient can prevent babies from brain disorders caused by cold or flu in pregnancy, say researchers.

The study showed that higher levels of choline prevented brain problems and mental illness, like attention deficit disorder and schizophrenia, in babies even when the mother had cold or flu during pregnancy.

“Cold and flu are often unavoidable, even if the mother has had a flu shot. But cold and flu during pregnancy double the risk of future mental illnesses. More and more information show choline helps the baby’s brain develop properly,” said Robert Freedman, Professor at the University of Colorado in the US.

baby
The study showed that higher levels of choline prevented brain problems and mental illness, like attention deficit disorder and schizophrenia, in babies even when the mother had cold or flu during pregnancy. Pixabay

“We found higher levels of choline prevent foetal brain problems from developing, even when the mother is infected. Choline supplements in pregnancy can have a lifelong benefit for the infant,” Freedman said.

For the study, published in the Journal of Paediatrics, the team assessed prenatal maternal infection, C-Reactive Protein (CRP) — a marker of maternal inflammation — and the mothers’ choline levels.

Brain development before birth was assessed by measuring the baby’s brain waves soon after birth.

baby
Choline supplements in pregnancy can have a lifelong benefit for the infant,” Freedman said.
Pixabay

When mothers had a cold or flu during the first 16 weeks of pregnancy, the newborns’
ability to cease or delay the effect on the brain decreased by 27 per cent.

Maternal flu also decreased children’s ability to pay attention and play.

Also Read: Study Warns Patients That Now Drugs Contain Inactive Ingredient

However, these effects were prevented if the mother had higher choline levels, the findings showed.

While the body creates some choline on its own and it is also naturally present in certain foods, including liver, red meat and eggs, pregnant women are recommended 450 mg of choline a day to improve babies’ brain development. (IANS)