Monday July 23, 2018

Bacteria in The Gut May Lead to Anxiety, Depression

The researchers are now working to identify specific populations of bacteria involved in these processes and the molecules that the bacteria produce

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Probiotics Not Effective in Reducing Anxiety: Study
Probiotics Not Effective in Reducing Anxiety: Study. Pixabay
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Gut bacteria plays a key role in infusing negative feelings in the brains of obese people, causing depression and anxiety, researchers say.

The findings showed that mice on a high-fat diet showed significantly more signs of anxiety, depression and obsessive behaviour than animals on standard diets.

In mice with high-fat diets, two areas of the brain, the hypothalamus, which helps to control whole body metabolism, and the nucleus accumbens, important in mood and behaviour, becomes insulin resistant.

“Your diet isn’t always necessarily just making your blood sugar higher or lower; it’s also changing a lot of signals coming from gut microbes and these signals make it all the way to the brain,” said C. Ronald Kahn, from the Joslin Diabetes Centre in the US.

“But all of these behaviours are reversed or improved when antibiotics that will change the gut microbiome were given with the high fat diet,” Kahn added.

Gut Bacteria.
Gut Bacteria. Pixabay

In the study, published in the journal Molecular Psychiatry, the team identified the effect of the microbiome by transferring gut bacteria from experimental mice to germ-free mice which did not have any bacteria of their own.

The animals which received bacteria from mice on a high-fat diet began to show increased levels of activity associated with anxiety and obsessive behaviour.

However, those who got microbes from mice on a high-fat diet plus antibiotics did not, even though they did not receive the antibiotics themselves.

Also Read: Depression, Anxiety May Lead to Teeth Loss

The researchers are now working to identify specific populations of bacteria involved in these processes and the molecules that the bacteria produce.

“If we could modify those bacteria, either by putting in more beneficial bacteria or reducing the number of harmful bacteria, that might be a way to see improved behaviour,” Kahn noted. (IANS)

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Greening Vacant Lots can Reduce Depression in Urban Areas

The findings support that exposure to more natural environments can be part of restoring mental health, particularly for people living in stressful and chaotic urban environments

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Greening vacant land is a highly inexpensive and scalable way to improve cities and enhance people's health.
Greening vacant land is a highly inexpensive and scalable way to improve cities and enhance people's health. Pixabay

Greening sidewalks, parks and vacant or dilapidated spaces could be an important and inexpensive tool to help address the rising cases of depression, anxiety and stress in urban communities, suggests a study.

“Dilapidated and vacant spaces are factors that put residents at an increased risk of depression and stress and may explain why socioeconomic disparities in mental illness persist,” said lead author Eugenia South, Assistant Professor at the University of Pennsylvania in the US.

“Greening vacant land is a highly inexpensive and scalable way to improve cities and enhance people’s health… while mental health therapies will always be a vital aspect of treatment. Revitalizing the places where people live, work and play may have broad, population-level impact on mental health outcomes,” added Charles Branas, Professor at the varsity.

In an experiment, published in JAMA Network Open, the research team measured the mental health of 342 Philadelphia residents before and after 541 vacant lots had been converted into green spaces as well as residents living near untreated abandoned lots, and those that just received trash clean-up.

In neighbourhoods below the poverty line, the feelings of depression among residents who lived near green lots decreased significantly by more than 68 per cent.
In neighbourhoods below the poverty line, the feelings of depression among residents who lived near green lots decreased significantly by more than 68 per cent. Pixabay

They found that people living within a quarter of a mile radius of greened lots had a 41.5 per cent decrease in feelings of depression compared to those who lived near the lots that had not been cleaned.

Those living near green lots also experienced a nearly 63 per cent decrease in self-reported poor mental health compared to those living near lots that received no intervention.

“What these new data show us is that making structural changes, like greening lots, has a positive impact on the health of those living in these neighbourhoods. And that it can be achieved in a cost-effective and scalable way,” Branas said.

Also Read: HIV Drug Is Not Linked to Depression: Study

In neighbourhoods below the poverty line, the feelings of depression among residents who lived near green lots decreased significantly by more than 68 per cent.

“The findings support that exposure to more natural environments can be part of restoring mental health, particularly for people living in stressful and chaotic urban environments,” the researchers said. (IANS)