Monday February 19, 2018

Being Overweight is not good for your Body and Brain, say Researchers

Researchers from the University of Arizona say having a high body mass index, or BMI, can cause inflammation that can impair cognitive functioning in older adults

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In this May 8, 2014 photo, an overweight man wears a shirt patterned after the American flag during a visit to the World Trade Center, in New York. VOA
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  • “The higher your BMI, the more your inflammation goes up,” said Kyle Bourassa, lead author of the study, which is published in the journal Brain, Behavior and Immunity
  • The researchers say their study adds to existing literature about inflammation and cognitive decline by showing BMI has a role to play
  • While cognitive decline is normal as one gets older, linking BMI to inflammation could help stave off the worst effects

October 19, 2016: Being overweight is not good for your body, and new research suggests it’s not good for your brain either. Researchers from the University of Arizona say having a high body mass index, or BMI, can cause inflammation that can impair cognitive functioning in older adults.

“The higher your BMI, the more your inflammation goes up,” said Kyle Bourassa, lead author of the study, which is published in the journal Brain, Behavior and Immunity. “Prior research has found that inflammation, particularly in the brain, can negatively impact brain function and cognition.”

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The conclusions were reached using data from the English Longitudinal Study of Aging, which “includes over 12 years’ worth of information on the health, well-being and social and economic circumstances of the English population age 50 and older.”

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They looked specifically at two groups over a six-year period.

“The higher participants’ body mass at the first time point in the study, the greater the change in their CRP levels over the next four years,” Bourassa said. “CRP stands for C-reactive protein, which is a marker in the blood of systemic inflammation in your body. Change in CRP over four years then predicted change in cognition six years after the start of the study. The body mass of these people predicted their cognitive decline through their levels of systemic inflammation.”

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“The findings provide a clear and integrative account of how BMI is associated with cognitive decline through systemic inflammation, but we need to remember that these are only correlational findings,” he said. “Of course, correlation does not equal causation. The findings suggest a mechanistic pathway, but we cannot confirm causality until we reduce body mass experimentally, then examine the downstream effects on inflammation and cognition.”

While cognitive decline is normal as one gets older, linking BMI to inflammation could help stave off the worst effects.

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“If you have high inflammation, in the future we may suggest using anti-inflammatories not just to bring down your inflammation but to hopefully also help with your cognition,” Bourassa said. “Having a lower body mass is just good for you, period. It’s good for your health and good for your brain.” (VOA)

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Combat obesity with your body’s built-in weighing scale

The system, which regulates weight gain by calculating body weight and fat mass, can help understanding the causes of obesity and ca facilitate new anti-obesity drugs.

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Obesity can now be cured by our body's natural weighing scales.
Obesity can now be cured by our body's natural weighing scales.
  • Human body’s natural weighing scales can now help cure obesity.
  • The study of these scales can help us understand the reasons and cures for obesity.

Human body consists of an internal body weight sensing system that operates like bathroom scales, registering body weight and signalling the brain to reduce food intake, researchers have found.

The system, which regulates weight gain by calculating body weight and fat mass, could lead to a better understanding of the causes of obesity as well as new anti-obesity drugs.

The results also explain why several studies have coupled sitting habit with obesity and bad health. It is because the “internal body scales give an inaccurately low measure when you sit down. As a result you eat more and gain weight,” the researchers said.

Sitting has been closely associated by the researchers, as a cause of obesity,
Sitting has been closely associated by the researchers, as a cause of obesity,

“We have found support for the existence of internal bathroom scales. The weight of the body is registered in the lower extremities. If the body weight tends to increase, a signal is sent to the brain to decrease food intake and keep the body weight constant,” said John-Olov Jansson, Professor at Sahlgrenska Academy, University of Gothenburg in Sweden.

Further, the results demonstrate that the weight sensing system regulates fat mass independently of leptin — a weight loss hormone. It is possible that leptin combined with activation of the internal body scales can become an effective treatment for obesity, the researchers said.

For the study, published in the journal Proceedings of the National Academy of Sciences (PNAS), the team performed experiments on obese rodents that were made artificially heavier by loading with extra weights.

The animals lost almost as much weight as the artificial load. The extra weights caused body fat to decrease and blood glucose levels to improve. IANS