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Biosensor to display the progress of Alzheimer’s disease

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image source: convergence.ucsb.edu

New York: A team of researchers led by an Indian-American scientist has developed a portable biosensor that can display the progress of Alzheimer’s disease in a patient.

A test on the cheap and simple biosensor can measure the level of a protein called beta-amyloid, increased level of which leads to the degeneration of brain cells and causes Alzheimer’s, in the blood at tiny concentrations in just half an hour.

“We want to develop a point of care system, where a small drop of blood plasma can reveal their beta-amyloid level immediately so that a doctor can tailor a patient’s therapy immediately,” said lead author Ajeet Kaushik from the University of Florida in the US.

The protein, which is found in lower levels in the blood, makes it a useful biomarker to diagnose and monitor the disease progression.

A quick test on the biosensor can reveal a clinician to collect accurate information on the progression of the disease and see what is happening to a patient over time.

It will also show if and when the disease reaches an untreatable level, the authors reported in the study published in the journal Biosensors and Bioelectronics.

The researchers pointed out that the affordable test can be useful in both developed countries and rural settings. Also with the right data, doctors can respond quickly to changes in a patient’s brain by reducing or increasing their dose of drugs. (IANS)

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Weight Gain in Mid-20s is Linked to Early Death, Study Says

According to the study published in the BMJ journal, weight loss at older ages (from middle to late adulthood) was also linked to higher risk

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Weight loss at older ages , Apart from Weight gain (from middle to late adulthood) is also linked to higher risk. Pixabay

Weight Gain from your mid-20s into middle age is associated with an increased risk of premature death, warn researchers.

According to the study published in the BMJ journal, weight loss at older ages (from middle to late adulthood) was also linked to higher risk.

“The results highlight the importance of maintaining normal weight across adulthood, especially preventing weight gain in early adulthood, for preventing premature deaths in later life,” said study researchers from China.

For the study, researchers based in China set out to investigate the association between weight changes across adulthood and mortality.

Their findings were based on data from the 1988-94 and 1999-2014 US National Health and Nutrition Examination Survey (NHANES), a nationally representative annual survey that includes interviews, physical examinations and blood samples, to gauge the health of the US citizens.

Their analysis included 36,051 people aged 40 years or over with measured body weight and height at the start of the survey (baseline) and recalled weight at young adulthood (25 years old) and middle adulthood (average age 47 years).

Deaths from any cause and specifically from heart diseases were recorded for an average of 12 years, during which time there were 10,500 deaths.

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Weight Gain from young to middle adulthood was associated with increased risk of mortality, compared with participants who remained at normal weight. Pixabay

After taking account of potentially influential factors, the researchers found that people who remained obese throughout adult life had the highest risk of mortality, while people who remained overweight throughout adult life had a very modest or no association with mortality.

Weight gain from young to middle adulthood was associated with increased risk of mortality, compared with participants who remained at normal weight.

Weight loss over this period was not significantly related to mortality.

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But as people got older, the association between weight gain and mortality weakened, whereas the association with weight loss from middle to late adulthood became stronger and significant. (IANS)