Sunday December 16, 2018
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Biosensor to display the progress of Alzheimer’s disease

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image source: convergence.ucsb.edu

New York: A team of researchers led by an Indian-American scientist has developed a portable biosensor that can display the progress of Alzheimer’s disease in a patient.

A test on the cheap and simple biosensor can measure the level of a protein called beta-amyloid, increased level of which leads to the degeneration of brain cells and causes Alzheimer’s, in the blood at tiny concentrations in just half an hour.

“We want to develop a point of care system, where a small drop of blood plasma can reveal their beta-amyloid level immediately so that a doctor can tailor a patient’s therapy immediately,” said lead author Ajeet Kaushik from the University of Florida in the US.

The protein, which is found in lower levels in the blood, makes it a useful biomarker to diagnose and monitor the disease progression.

A quick test on the biosensor can reveal a clinician to collect accurate information on the progression of the disease and see what is happening to a patient over time.

It will also show if and when the disease reaches an untreatable level, the authors reported in the study published in the journal Biosensors and Bioelectronics.

The researchers pointed out that the affordable test can be useful in both developed countries and rural settings. Also with the right data, doctors can respond quickly to changes in a patient’s brain by reducing or increasing their dose of drugs. (IANS)

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A Comprehensive Study Of Parasitic Worms Release Numerous Anwers

The analysis found almost a million new genes that had not been seen before, belonging to thousands of new gene families, and identified many new potential drug targets and drugs.

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parasitic Worm
A giant 25m worm representing the parasitic worm of schistosomiasis, that causes significant suffering and death to thousands of people around the world, is pictured on the Lake Leman on the occasion of the Neglected Tropical Diseases Summit, in Geneva, Switzerland. VOA

The largest study to date of the genetic makeup of parasitic worms has found hundreds of new clues about how they invade the human body, evade its immune system and cause disease.

The results point to potential de-worming treatments to help fight some of the most neglected tropical diseases — including river blindness, schistosomiasis and hookworm disease — which affect around a billion people worldwide.

“Parasitic worms are some of our oldest foes and have evolved over millions of years to be expert manipulators of the human immune system,” said Makedonka Mitreva of Washington University’s McDonnell Genome Institute, who co-led the work with colleagues from Britain’s Wellcome Sanger Institute and Edinburgh University.

parasitic Worm
World’s longest tapeworm. wikimedia

She said the results of this study would lead to both a deeper knowledge of the biology of parasites and a better understanding of how human immune systems can be harnessed or controlled.

Parasitic worm infections can last many years and can cause severe pain, physical disabilities, retarded development in children and social stigma linked to deformity.

Current medicines to combat them — including drugs made by Sanofi, GSK and Johnson & Johnson — can be moderately effective and are often donated by drugmakers or sold at reduced prices to those who need them. But the spectrum of drugs to treat worm infections is still limited.

To try to improve the potential drug pipeline and to understand how worms invade and take up residence inside humans and other animals, the research team compared the genomes of 81 species of roundworms and flatworms, including 45 that had never previously had their genomes sequenced.

parasitic Worm
How gut microbiota can aid in early diagnosis of liver cancer.

The analysis found almost a million new genes that had not been seen before, belonging to thousands of new gene families, and identified many new potential drug targets and drugs.

Also Read: Genes Tied To Obesity May Lower Risk Of Diabetes

“We focused our search by looking at existing drugs for human illnesses,” said the Sanger Institute’s Avril Coghlan, who worked on the team. She said this offered a possible fast-track route “to pinpointing existing drugs that could be repurposed for deworming.”

The study’s findings were published Monday in the journal Nature Genetics. (VOA)