Thursday January 24, 2019

Combat obesity with your body’s built-in weighing scale

The system, which regulates weight gain by calculating body weight and fat mass, can help understanding the causes of obesity and ca facilitate new anti-obesity drugs.

0
//
Obesity can now be cured by our body's natural weighing scales.
Obesity can now be cured by our body's natural weighing scales.
  • Human body’s natural weighing scales can now help cure obesity.
  • The study of these scales can help us understand the reasons and cures for obesity.

Human body consists of an internal body weight sensing system that operates like bathroom scales, registering body weight and signalling the brain to reduce food intake, researchers have found.

The system, which regulates weight gain by calculating body weight and fat mass, could lead to a better understanding of the causes of obesity as well as new anti-obesity drugs.

The results also explain why several studies have coupled sitting habit with obesity and bad health. It is because the “internal body scales give an inaccurately low measure when you sit down. As a result you eat more and gain weight,” the researchers said.

Sitting has been closely associated by the researchers, as a cause of obesity,
Sitting has been closely associated by the researchers, as a cause of obesity,

“We have found support for the existence of internal bathroom scales. The weight of the body is registered in the lower extremities. If the body weight tends to increase, a signal is sent to the brain to decrease food intake and keep the body weight constant,” said John-Olov Jansson, Professor at Sahlgrenska Academy, University of Gothenburg in Sweden.

Further, the results demonstrate that the weight sensing system regulates fat mass independently of leptin — a weight loss hormone. It is possible that leptin combined with activation of the internal body scales can become an effective treatment for obesity, the researchers said.

For the study, published in the journal Proceedings of the National Academy of Sciences (PNAS), the team performed experiments on obese rodents that were made artificially heavier by loading with extra weights.

The animals lost almost as much weight as the artificial load. The extra weights caused body fat to decrease and blood glucose levels to improve. IANS

Next Story

Study Reveals That Genes Affect Where Fat is Stored in our Bodies

The result of the current study may therefore lead to the development of new interventions to reduce the risk of cardiovascular disease

0
The heart attack brings about activation of certain genes which stay as a permanent memory in genes. Pixabay

Researchers have found that whether you store your fat around the trunk or in other parts of your body is highly influenced by genetic factors.

The study, published in the journal Nature Communications, also reported that this effect is present predominantly in women and to a much lower extent in men.

“We know that women and men tend to store fat differently – women have the ability to more easily store fat on the hips and legs, while men tend to accumulate fat around the abdomen to a higher extent,” said lead author Mathias Rask-Andersen from Uppsala University in Sweden.

“This has been attributed to the effects of sex hormones such as estrogen. But the molecular mechanisms that control this phenomenon are fairly unknown,” Rask-Andersen added.

For the study, the researchers measured how fat was distributed in nearly 360,000 voluntary participants. The participants gave blood samples for genotyping and the distribution of fat tissue was estimated using impedance measurements, i.e. measurements of electrical resistance when an electrical current is fed through the body.

In the study, millions of genetic variants across the genome were tested for association with distribution of fat to the arms, legs or trunk, and the research team identified nearly a hundred genes that affect distribution of adipose tissue to the different compartments of the human body.

Representational image.

The researchers also saw a high degree of heterogeneity between sexes.

The findings suggest that remodelling of the extracellular matrix is one of the mechanisms that generates differences in body fat distribution, the researchers said.

Fat stored in the trunk has previously been associated with increased disease risk. Men have a greater amount of abdominal fat than women and this may explain the increased prevalence of cardiovascular disease observed in males.

Epidemiological studies have even shown that the ability to store fat around the hips and legs gives women some protection against cardiovascular disease.

Also Read- Samsung Unveils its Latest Processor For Mid-ranged Smartphones in India

The result of the current study may therefore lead to the development of new interventions to reduce the risk of cardiovascular disease.

“The biological systems we highlight in our study have the potential to be used as points-of-intervention for new drugs that are aimed at improving the distribution of body fat and thereby reducing the risk of disease,” Mathias Rask-Andersen noted. (IANS)