Saturday April 20, 2019

Combination of Drugs for Diabetes and Hypertension may offer an effective new way to combat Cancer

the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed "suicide".

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Suicide for cancer cells via a combination drug
A combination drug of diabeties and hypertension to cure cancer,pixabay

London, December 28, 2016: A combination of drugs for diabetes and hypertension may offer an effective new way to combat cancer, suggests a new research.

In their experiments, the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed “suicide”.

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 “We have been able to show that the two known drugs lead to more profound effects on cancer cell proliferation than each drug alone,” said study first author Don Benjamin from the University of Basel in Switzerland.

“The data from this study support the development of combination approaches for the treatment of cancer patients,” Benjamin noted.

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Metformin is a widely prescribed drug for the treatment of Type-2 diabetes.

Besides its blood sugar lowering effect, it also displays anti-cancer properties. The usual therapeutic dose, however, is too low to effectively fight cancer.

At higher doses, the antidiabetic drug inhibits the growth of cancer cells but could also induce unwanted side effects.

The new research published in the journal Science Advances showed that the antihypertensive drug syrosingopine enhances the anti-cancer efficacy of metformin.

The study showed the cocktail of these two drugs is effective in a wide range of cancers.

“For example, in samples from leukemia patients, we demonstrated that almost all tumour cells were killed by this cocktail and at doses that are actually not toxic to normal cells”, Benjamin said.

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“And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment,” Benjamin noted.

In mice with malignant liver cancer, enlargement of the liver was reduced after the therapy. Also the number of tumor nodules was less — in some animals the tumours disappeared completely.

The researchers found that the drugs interrupt the vital processes which provide energy for the cancer cell. (IANS)

  • Ruth

    I don’t like drink cocktail.

Next Story

Researchers Develop, New Adhesive Patch That Can Minimize Heart Attack Damage

For the research, published in Nature Biomedical Engineering, the team tested the patch with rats and showed that the patch could be effective in reducing post-heart attack damage. 

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The researchers said the patch, which costs "less than a penny", has been optimised using a computer model of the heart to perfectly match the material's mechanical properties. Pixabay

Researchers have developed a new adhesive patch that could reduce the stretching of cardiac muscle following a heart attack.

Developed by a team of researchers from Brown University, US; Fudan University, China and Soochow University, China, the patch is made from a water-based hydrogel material and can be placed directly on the heart to prevent left ventricular remodelling — a stretching of the heart muscle.

A heart attack puts the cardiac muscle at a risk of stretching out that can reduce the functioning of the heart’s main pumping chamber.

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The researchers say the initial results are promising for eventual use in human clinical trials. Pixabay

“Part of the reason that it’s hard for the heart to recover after a heart attack is that it has to keep pumping,” said co-author Huajian Gao, a professor at Brown University.

“The idea here is to provide mechanical support for damaged tissue, which hopefully gives it a chance to heal,” he added.

The researchers said the patch, which costs “less than a penny”, has been optimised using a computer model of the heart to perfectly match the material’s mechanical properties.

“If the material is too hard or stiff, then you could confine the movement of the heart so that it can’t expand to the volume it needs to,” Gao said.

“But if the material is too soft, then it won’t provide enough support. So we needed some mechanical principles to guide us,” he pointed out.

For the research, published in Nature Biomedical Engineering, the team tested the patch with rats and showed that the patch could be effective in reducing post-heart attack damage.

heart
A heart attack puts the cardiac muscle at a risk of stretching out that can reduce the functioning of the heart’s main pumping chamber. Pixabay

“The patch provided nearly optimal mechanical supports after myocardial infarction (i.e. massive death of cardiomyocytes),” said co-author Ning Sun, a cardiology researcher at Fudan University.

“[It] maintained a better cardiac output and thus greatly reduced the overload of those remaining cardiomyocytes and adverse cardiac remodelling.”

Also Read: China’s Political System Helps It To Take A Lead in Artificial Intelligence

The researchers say the initial results are promising for eventual use in human clinical trials.

“It remains to be seen if it will work in humans, but it’s very promising,” Gao said. (IANS)