Wednesday February 20, 2019

Combination of Drugs for Diabetes and Hypertension may offer an effective new way to combat Cancer

the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed "suicide".

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Suicide for cancer cells via a combination drug
A combination drug of diabeties and hypertension to cure cancer,pixabay

London, December 28, 2016: A combination of drugs for diabetes and hypertension may offer an effective new way to combat cancer, suggests a new research.

In their experiments, the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed “suicide”.

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 “We have been able to show that the two known drugs lead to more profound effects on cancer cell proliferation than each drug alone,” said study first author Don Benjamin from the University of Basel in Switzerland.

“The data from this study support the development of combination approaches for the treatment of cancer patients,” Benjamin noted.

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Metformin is a widely prescribed drug for the treatment of Type-2 diabetes.

Besides its blood sugar lowering effect, it also displays anti-cancer properties. The usual therapeutic dose, however, is too low to effectively fight cancer.

At higher doses, the antidiabetic drug inhibits the growth of cancer cells but could also induce unwanted side effects.

The new research published in the journal Science Advances showed that the antihypertensive drug syrosingopine enhances the anti-cancer efficacy of metformin.

The study showed the cocktail of these two drugs is effective in a wide range of cancers.

“For example, in samples from leukemia patients, we demonstrated that almost all tumour cells were killed by this cocktail and at doses that are actually not toxic to normal cells”, Benjamin said.

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“And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment,” Benjamin noted.

In mice with malignant liver cancer, enlargement of the liver was reduced after the therapy. Also the number of tumor nodules was less — in some animals the tumours disappeared completely.

The researchers found that the drugs interrupt the vital processes which provide energy for the cancer cell. (IANS)

  • Ruth

    I don’t like drink cocktail.

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Low Cure Rate For Childhood Cancer in India: Experts

On International Childhood Cancer Day, the hospital organised a ‘Sit and Draw competition’ with pediatric patients and rewarded the winner

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Health insurance covers only for hospitalization and doesn’t necessarily cover the medical expenses incurred for the treatment of major illnesses. flickr

Childhood cancer comprises almost 3-5 per cent of the total cancer cases in India, experts said here on Friday, expressing concern over the low cure rate due to lack of available data.

“The disturbing reality is that the cure rate of pediatric cancer is almost 80 per cent in the developed countries. When we see the data from major cancer centres, it actually can match up to the Western standard but this data is not enough,” Haemato-Oncologist Vivek Agarwala said at an awareness programme conducted by Narayana Superspecialty Hospital, Howrah.

According to the Indian Council for Medical Research, cancer in children constitutes approximately 3-5 per cent of the total cancer cases in India.

Agarwala said a large portion of the incidence of childhood cancer in society is still not addressed.

Cancer survivor. Flickr

Also, a large section who don’t have access to premier institutes are often diagnosed late due to financial crunch and that is why the overall treatment rate in India is low.

“Probably, the government and society at large are not considering it a big problem as it is just around 5 per cent. We are always campaigning for breast and cervical cancers,” Agarwala said.

“We must remember this 5 per cent of cancer is majorly curable if given proper treatment,” he said.

Leukaemia and retinoblastoma (a form of cancer where children have a white eye) are the two common forms of cancer in children.

Also Read- Push-ups Can Lower The Risk of Heart Diseases

Talking about awareness and symptoms that parents need to watch out for, he said: “Symptoms are different for different cancers, but children who have cancer have poor growth, poor weight gain and decreased appetite. One must get their children evaluated on seeing these symptoms”.

On International Childhood Cancer Day, the hospital organised a ‘Sit and Draw competition’ with pediatric patients and rewarded the winner. (IANS)