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Combination of Drugs for Diabetes and Hypertension may offer an effective new way to combat Cancer

the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed "suicide".

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Suicide for cancer cells via a combination drug
A combination drug of diabeties and hypertension to cure cancer,pixabay

London, December 28, 2016: A combination of drugs for diabetes and hypertension may offer an effective new way to combat cancer, suggests a new research.

In their experiments, the researchers found that the combination of the diabetes drug metformin and the antihypertensive drug syrosingopine drives cancer cells to programmed “suicide”.

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 “We have been able to show that the two known drugs lead to more profound effects on cancer cell proliferation than each drug alone,” said study first author Don Benjamin from the University of Basel in Switzerland.

“The data from this study support the development of combination approaches for the treatment of cancer patients,” Benjamin noted.

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Metformin is a widely prescribed drug for the treatment of Type-2 diabetes.

Besides its blood sugar lowering effect, it also displays anti-cancer properties. The usual therapeutic dose, however, is too low to effectively fight cancer.

At higher doses, the antidiabetic drug inhibits the growth of cancer cells but could also induce unwanted side effects.

The new research published in the journal Science Advances showed that the antihypertensive drug syrosingopine enhances the anti-cancer efficacy of metformin.

The study showed the cocktail of these two drugs is effective in a wide range of cancers.

“For example, in samples from leukemia patients, we demonstrated that almost all tumour cells were killed by this cocktail and at doses that are actually not toxic to normal cells”, Benjamin said.

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“And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment,” Benjamin noted.

In mice with malignant liver cancer, enlargement of the liver was reduced after the therapy. Also the number of tumor nodules was less — in some animals the tumours disappeared completely.

The researchers found that the drugs interrupt the vital processes which provide energy for the cancer cell. (IANS)

  • Ruth

    I don’t like drink cocktail.

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Smoking May Increase Risk of Developing Hypertension, Warn Researchers

The results were published in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

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FILE - New findings show that smoking causes devastating genetic damage, or mutations, in the cells of various organs in the body. VOA

Smoking may increase the risk of developing hypertension by impairing the body’s blood pressure autocorrect system, warn researchers.

“The human body has a buffering system that continuously monitors and maintains a healthy blood pressure. If blood pressure drops, a response called muscle sympathetic nerve activity (MSNA) is triggered to bring blood pressure back up to normal levels,” said Lawrence Sinoway from Penn State University in the US.

An additional system — called the baroreflex — helps correct if blood pressure gets too high, he added.

According to Sinoway, the study found that after a burst of MSNA, the rise in blood pressure in a chronic smoker was about twice as great as in a non-smoker, pushing blood pressure to unhealthy levels. The researchers suspect that impairment of baroreflex may be the culprit.

“When the sympathetic nervous system fires, like with MSNA, your blood pressure rises and then a series of things happen to buffer that increase, to try to attenuate it,” Sinoway said.

“We think that in smokers, that buffering — the baroreflex — is impaired.”

Other than chronic diseases, lifestyle habits like smoking causes cancer too. Pixabay
Other than chronic diseases, lifestyle habits like smoking causes cancer too. Pixabay

The results suggest that this impairment may be connected to hypertension, said Jian Cui, Associate Professor at Penn State College of Medicine.

“The greater rise in blood pressure in response to MSNA may contribute to a higher resting blood pressure level in smokers without hypertension,” Cui said.

“It’s possible that this higher response to MSNA could also contribute to the eventual development of hypertension,” Cui added.

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The researchers said that while previous research has found a link between chronic smokers and higher levels of MSNA bursts, less was known about what happened to blood pressure after these bursts.

For the study, the researchers examined 60 participants — 18 smokers and 42 non-smokers. None of the participants had hypertension.

The results were published in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. (IANS)