Monday, May 10, 2021
Home Life Style Health & Fitness Diabetes, Cancer & Pesticide Exposure May Raise Covid Risk: Study

Diabetes, Cancer & Pesticide Exposure May Raise Covid Risk: Study

The team examined whether exposure to the organophosphate pesticide chlorpyriphos and increased levels of interleukin 6 (IL-6) could increase the risk of SARS-CoV-2 infection

People with metabolic diseases like Type-2 diabetes and cancer as well as those exposed to organophosphate pesticides can be at an increased risk of Covid-19 infection, finds a new study performed in human lung airway cells. The study, led by Saurabh Chatterjee and the team from the University of South Carolina in the US, identified a basic mechanism linked with inflammation that could increase susceptibility to Covid-19 infection among people exposed to organophosphates.

The findings showed that people with Type-2 diabetes and cancer may also be at increased risk to Covid because they tend to exhibit the same type of inflammation. Exposure to organophosphate pesticides causes Gulf War Illness — a cluster of medically unexplained chronic symptoms that can include fatigue, headaches, joint pain, indigestion, insomnia, dizziness, respiratory disorders, and memory problems.

Follow NewsGram on Facebook to stay updated.

The team examined whether exposure to the organophosphate pesticide chlorpyriphos and increased levels of interleukin 6 (IL-6) could increase the risk of SARS-CoV-2 infection. For six hours, they exposed human lung airway epithelial cells to either IL-6 or chlorpyriphos or to both in combination. Another group of cells received no exposure to serve as a control.

Pesticide
The findings will be presented at the virtual Experimental Biology (EB) 2021 meeting to be held on April 27-30. Pixabay

The researchers then treated the cells with the spike proteins that cover the outside of SARS-CoV-2. During infection, spike proteins bind with angiotensin-converting enzyme 2 (ACE2) receptors to our cells, starting a process that allows the virus to release its genetic material into the healthy cell. They found that cells exposed to IL-6 and the pesticide exhibited increased apoptosis — or controlled cell death — when the SARS-CoV-2 spike protein was present.

ALSO READ: Experts Recommend ‘Smell Training’ To Combat Scent Loss Caused By Covid-19

The cells exposed to both the pesticide and IL-6 also had significantly more ACE2 expression on the apical cell surface compared to cells that were unexposed or exposed to the pesticide alone. The apical membrane of airway cells faces the interior of the airway while the basolateral membrane touches the surrounding tissues. Increased ACE2 receptor expression on the apical surface means more viruses will attach to the cells, the researchers explained.

“Since people with obesity, Type-2 diabetes or cancer also have high circulatory IL-6 levels, we think people with these conditions will also have increased susceptibility to SARS-CoV-2 infection because of increased translocation of ACE2 receptor to the apical cell surface,” Chatterjee said. The findings will be presented at the virtual Experimental Biology (EB) 2021 meeting to be held on April 27-30. (IANS/JC)

STAY CONNECTED

19,511FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

Vegetarian Cuisine From The Himalayan Foothills: By Veena Sharma

Author and gastronomist Veena Sharma have always believed that one's kitchen is one's best pharmacy, providing us with the particular admixtures and combinations that...

Only 13% Of Global iOS Users Allow Apps To Track To Date After iOS 14.5 Update

After Apple introduced its app tracking transparency tool with iOS 14.5 update to give users better control over their privacy, only 13 percent of...

Coronavirus Protocols To Quickly Identify Mutants Developed By Scientists

A worldwide network of scientists has isolated functional units of the SARS-CoV-2 proteins in such a way that their structure, function, and interactions can...

The AIIMS Guidelines On “Do’s And Dont’s” In Home Isolation

The AIIMS has given guidelines on Covid management in home isolation at a recent training session for 14 experts from tertiary care centers across...

Fauci Says Wearing Masks Could Become Seasonal Following The Pandemic

Wearing face masks may become seasonal when respiratory illnesses are more prevalent, says US top infectious disease expert Anthony Fauci. Fauci said he thinks...

Skeema: This Tool Will Assist You In Managing Your Browser Tabs More Effectively

If you are reading this, chances are you have several other tabs open in your browser. Are you facing trouble with the overloading of...

Why Did Bharatiya Janata Party (BJP) Fail To Secure Hindu Votes In West Bengal?

Though the BJP has increased its tally in the West Bengal Assembly from three in 2016 to 77 in 2021 - a substantial increase...

Study: Organ Transplants Recipients Are Susceptible To Covid-19

Patients, who had organ transplants, remain vulnerable to Covid-19 infections even after a second vaccine dose, finds a study that urges people who are...

Recent Comments