Sunday September 22, 2019

Distress May Spike up Risk of Dementia

For the study, the team included 6,807 Danish participants aged 60 years on average

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Men and women who are distressed in midlife could be at higher risk of developing dementia in their old age, suggests a new study.

The study showed that vital exhaustion, which can be perceived as an indicator of psychological distress, is a risk factor for future risk of dementia.

Psychological distress is potentially linked to the risk of dementia through neurological and cardiovascular mechanisms.

The findings, led by researchers from the University of Copenhagen in Denmark, revealed that for each additional symptom of vital exhaustion, the risk of dementia rose by two per cent.

While participants reporting five to nine symptoms had a 25 per cent higher risk of dementia than those with no symptoms, those reporting 10 to 17 symptoms had a 40 per cent higher risk of dementia compared with not having symptoms.

However, the researchers are yet not aware of "exactly how anticholinergics might cause dementia", the researchers said.
Representational Image- dementia, Pixabay

Importantly, physiological stress response, including cardiovascular changes and excessive production of cortisol over a prolonged period, may also contribute to linking psychological distress with an increased risk of dementia, revealed the study published in the Journal of Alzheimer’s Disease.

“Stress can have severe and harmful consequences not just for our brain health, but our health in general. Cardiovascular risk factors are well-known modifiable risk factors for dementia, and in some countries, a stagnation or even a decreasing incidence of dementia has been observed,” said Sabrina Islamoska, postdoctoral student from the varsity.

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For the study, the team included 6,807 Danish participants aged 60 years on average.

Psychological distress is an important risk factor that should receive more focus when considering prevention initiatives in relation to later dementia, the team said. (IANS)

Next Story

Donepezil, A Drug Used For Alzheimer Disease, Doubles Hospitalisation Risk

Researchers have found that a drug, donepezil commonly used to manage symptoms of Alzheimer disease and other forms of dementia, is associated with a two-fold higher risk of hospitalisation

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Drugs, Alzheimer, Dementia, Hospitalisation, Risk
Dementia is a growing problem, with almost 10 million newly diagnosed cases every year around the world. Pixabay

Researchers have found that a drug, donepezil commonly used to manage symptoms of Alzheimer disease and other forms of dementia, is associated with a two-fold higher risk of hospitalisation.

According to the study published in the journal Canadian Medical Association Journal (CMAJ), using donepezil increases the risk of hospital admission for rhabdomyolysis, a painful condition of muscle breakdown, compared with several other cholinesterase inhibitors.

Dementia is a growing problem, with almost 10 million newly diagnosed cases every year around the world, said the researchers.

Drugs, Alzheimer, Dementia, Hospitalisation, Risk
Dr. William Burke goes over a PET brain scan, Aug. 14, 2018 at Banner Alzheimers Institute in Phoenix, Arizona. VOA

“The findings of this population-based cohort study support regulatory agency warnings about the risk of donepezil-induced rhabdomyolysis,” said study researcher Jamie Fleet from McMaster University in Canada.

The study, led by researchers at Western University, looked at ICES data from 2002 to 2017 on 2,20,353 patients aged 66 years or older in Ontario, Canada, with a new prescription for donepezil, rivastigmine or galantamine, three cholinesterase inhibitors used to manage dementia and Alzheimer disease.

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The researchers found that donepezil was associated with a two-fold higher risk of hospitalisation for rhabdomyolysis, a serious condition that can result in kidney disease.

According to the findings, the relative risk was small but statistically significant. (IANS)