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Drug prescribed to Pregnant Women with history of delivering Premature Babies may do more Harm than Good: Study

The drug, mostly prescribed to pregnant women with a history of delivering premture babies may even increase the risk of developing gestational diabetes

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New York, March 15, 2017: A drug commonly prescribed to pregnant women with a history of delivering premature babies may do more harm than good, says a study.

Far from providing any benefit, this drug — known by the brand name Makena — may even increase the risk of developing gestational diabetes, said the study published online in the American Journal of Obstetrics and Gynecology.

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“Our study showed the drug to be ineffective, and it has a side effect,” said first author of the study David Nelson, Assistant Professor of Obstetrics and Gynecology at University of Texas Southwestern Medical Center (UT Southwestern) in the US.

The drug, a synthetic progestogen hormone called 17-alpha hydroxyprogesterone caproate, was approved by the US Food and Drug Administration (FDA) in 2011 to treat women at risk of delivering a second premature baby.

The FDA gave the drug accelerated approval in part due to findings in a 2003 study published in The New England Journal of Medicine that the drug reduced the likelihood of a repeat preterm delivery.

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However, Makena has been a source of debate among doctors because of the questions raised about the 2003 findings.

Earlier research findings on the benefit of 17-OHPC have been mixed, said Kenneth Leveno, senior author of the study and Professor of Obstetrics and Gynecology at UT Southwestern.

In the newly published study, pregnant women treated at Parkland Memorial Hospital, were offered the drug 17-alpha hydroxyprogesterone caproate (17-OHPC) if they had a prior history of premature births and were carrying a single fetus.

The research took place from 2012 to 2016 and followed 430 women treated with the drug.

Researchers then compared the premature birth rate of those women with the historical premature birth rate of 5,787 patients seen at Parkland between 1988 and 2011 — women who also had a history of premature delivery but never took the drug.

Of the women in the study group who took the drug, 25 per cent had a premature delivery.

That compared with a 16.8 per cent preterm birth rate in the historical nondrug group.

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The rate of gestational diabetes was 13.4 per cent in women treated with the drug, compared with eight per cent in the other group, the study found.

Gestational diabetes often goes away after the birth, and therefore is not usually a serious problem for the mother, Nelson said.

However, it can lead to deliveries of larger babies and increased chances for cesarean sections and other birth complications. (IANS)

 

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USA: Everything you want to know about Security Clearance; Find out here!

A security clearance allows a person access to classified national security information or restricted areas.

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Former CIA Director John O. Brennan speaks at the Council on Foreign Relations in Washington, March 11, 2014. President Donald Trump revoked Brennan's security clearance Wednesday. VOA
Former CIA Director John O. Brennan speaks at the Council on Foreign Relations in Washington, March 11, 2014. President Donald Trump revoked Brennan's security clearance Wednesday. VOA

U.S. President Donald Trump on Wednesday revoked the security clearance of former CIA Director John Brennan. We take a look at what that means.

What is a security clearance?

A security clearance allows a person access to classified national security information or restricted areas after completion of a background check. The clearance by itself does not guarantee unlimited access. The agency seeking the clearance must determine what specific area of information the person needs to access.

What are the different levels of security clearance?

There are three levels: Confidential, secret and top secret. Security clearances don’t expire. But, top secret clearances are reinvestigated every five years, secret clearances every 10 years and confidential clearances every 15 years.

All federal agencies follow a list of 13 potential justifications for revoking or denying a clearance. VOA
All federal agencies follow a list of 13 potential justifications for revoking or denying a clearance. VOA

Who has security clearances?

According to a Government Accountability Office report released last year, about 4.2 million people had a security clearance as of 2015, they included military personnel, civil servants, and government contractors.

Why does one need a security clearance in retirement?

Retired senior intelligence officials and military officers need their security clearances in case they are called to consult on sensitive issues.

Also Read: Governments Across The World Request Apple for 30,000 Device Information

Can the president revoke a security clearance?

Apparently. But there is no precedent for a president revoking someone’s security clearance. A security clearance is usually revoked by the agency that sought it for an employee or contractor. All federal agencies follow a list of 13 potential justifications for revoking or denying a clearance, which can include criminal acts, lack of allegiance to the United States, behavior or situation that could compromise an individual and security violations. (VOA)