Tuesday May 22, 2018

Drug prescribed to Pregnant Women with history of delivering Premature Babies may do more Harm than Good: Study

The drug, mostly prescribed to pregnant women with a history of delivering premture babies may even increase the risk of developing gestational diabetes

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New York, March 15, 2017: A drug commonly prescribed to pregnant women with a history of delivering premature babies may do more harm than good, says a study.

Far from providing any benefit, this drug — known by the brand name Makena — may even increase the risk of developing gestational diabetes, said the study published online in the American Journal of Obstetrics and Gynecology.

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“Our study showed the drug to be ineffective, and it has a side effect,” said first author of the study David Nelson, Assistant Professor of Obstetrics and Gynecology at University of Texas Southwestern Medical Center (UT Southwestern) in the US.

The drug, a synthetic progestogen hormone called 17-alpha hydroxyprogesterone caproate, was approved by the US Food and Drug Administration (FDA) in 2011 to treat women at risk of delivering a second premature baby.

The FDA gave the drug accelerated approval in part due to findings in a 2003 study published in The New England Journal of Medicine that the drug reduced the likelihood of a repeat preterm delivery.

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However, Makena has been a source of debate among doctors because of the questions raised about the 2003 findings.

Earlier research findings on the benefit of 17-OHPC have been mixed, said Kenneth Leveno, senior author of the study and Professor of Obstetrics and Gynecology at UT Southwestern.

In the newly published study, pregnant women treated at Parkland Memorial Hospital, were offered the drug 17-alpha hydroxyprogesterone caproate (17-OHPC) if they had a prior history of premature births and were carrying a single fetus.

The research took place from 2012 to 2016 and followed 430 women treated with the drug.

Researchers then compared the premature birth rate of those women with the historical premature birth rate of 5,787 patients seen at Parkland between 1988 and 2011 — women who also had a history of premature delivery but never took the drug.

Of the women in the study group who took the drug, 25 per cent had a premature delivery.

That compared with a 16.8 per cent preterm birth rate in the historical nondrug group.

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The rate of gestational diabetes was 13.4 per cent in women treated with the drug, compared with eight per cent in the other group, the study found.

Gestational diabetes often goes away after the birth, and therefore is not usually a serious problem for the mother, Nelson said.

However, it can lead to deliveries of larger babies and increased chances for cesarean sections and other birth complications. (IANS)

 

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Next Story

Simple Ways to Lose Belly Fat After Pregnancy

Capital-based Rita Bakshi, gynaecologist at the International Fertility Centre, suggests how to get back in shape post delivery

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Simple Ways to Lose Belly Fat After Pregnancy
Simple Ways to Lose Belly Fat After Pregnancy. Pixabay

Want to cut belly fat post-pregnancy? Choose fresh food over refrigerated one, don’t consume the same kind of dish everyday and chew well, says an expert.

Capital-based Rita Bakshi, gynaecologist at the International Fertility Centre, suggests how to get back in shape post delivery:

– Fresh fruits: When you eat fruits, remember not to refrigerate them for a long

– Freshly cooked food: Try having food that doesn’t include artificial preservatives and cut down on processed foods

Eat fresh fruits
Eat fresh fruits. Pixabay

– Seasonal vegetables: Seasonal vegetables and fruits are not only good for your body, but also bring about variation in your diet. Do not eat the same food every day as it is unhealthy. But don’t overeat

– Head for the park: Your body requires some time to get back to normal so the best advice would be to get started with general exercises beginning with brisk walking. Also, it is important to take your doctor’s advice before starting any workout regimen.

Also Read: 5 Healthy Ways To Get Back In Shape After Pregnancy

– Yoga: The right yoga asanas, pranayama will help you lose weight earlier than you actually thought. Join a yoga class and start with basics. It is good for physical and mental health

– Chew food: Chewing your food is equally important when you trying to get back to shape. It is a good mouth exercise (Bollywood Country)