Tuesday October 23, 2018

Ebola vaccine found effective against new strain

0
//
31
www.ibtimes.com
Republish
Reprint
www.firstpost.com
www.firstpost.com

New York: A single dose of an experimental Ebola virus (EBOV) vaccine completely protects monkeys against the newly emerged West African Ebola strain when given at least seven days before exposure, and partially protects them if given three days prior, says a new study.

The experimental vaccine is currently undergoing testing in a global clinical trial in humans.

The current Ebola outbreak has killed over 11,000 people mainly in Liberia, Sierra Leone and Guinea.

The positive results of this study further reveal the mechanisms by which an effective immune response is mounted against the Ebola virus, aspects of which have been unclear.

The live-attenuated vaccine, VSV-EBOV, uses genetically engineered vesicular stomatitis virus (VSV) to carry an EBOV gene that has safely induced protective immunity in macaques, the study noted.

In the study by Andrea Marzi from US National Institutes of Health (NIH) VSV-EBOV was administered to groups of macaques 28, 21, 14, seven, or three days before infection with the current outbreak strain EBOV-Makona.

No adverse effects were detectable after immunisation with the lethal dose, and the animals were then monitored for 42 days.

The control group, which was administered a vaccine known not to be effective, showed severe symptoms of Ebola and did not survive.

One animal in the day-three VSV-EBOV vaccination group also did not survive, while the other two animals in this group presented mild and moderate symptoms of Ebola but eventually cleared the virus.

All nine remaining animals in the day 28, 21, 14, and seven vaccination groups did not develop any clinical signs of disease.

(IANS)

Click here for reuse options!
Copyright 2015 NewsGram

Next Story

Ebola Not A Global Health Emergency: WHO

WHO advised DRC's nine neighboring countries that they were at high risk of having the disease spread into their territories

0

An emergency committee convened by the World Health Organization has decided that the Ebola outbreak in eastern Democratic Republic of the Congo does not constitute a public health emergency of international concern.

The WHO said Wednesday that 216 cases of Ebola and 139 deaths had been reported, and its International Health Regulations Emergency Committee said the outbreak was a matter of serious concern, especially since it is occurring in an area of conflict in eastern DRC. It said this posed problems for health workers who need to move around freely and track people who are infected with the virus and need treatment.

But the committee said that one reason it did not regard the outbreak as a global threat was that the virus had not spread into neighboring countries.

Congo,ebola
A Congolese health worker administers Ebola vaccine to a boy who had contact with an Ebola sufferer in the village of Mangina in North Kivu province of the Democratic Republic of the Congo. VOA

Committee Chairman Robert Steffan said the international response to the outbreak had been very good. He said WHO and other agencies had achieved quite a lot since the outbreak was declared Aug. 1. In fact, he said the disease was being brought under control in North Kivu province.

The disease is flaring up in another province, and the response is being concentrated in this area, he said, “so we do have some optimism that this outbreak, just like the one in May, will be brought under control within reasonable time.”

Steffan said the committee agreed that declaring an international emergency at this time would hinder efforts to contain the Ebola virus. He said a declaration would have implications for travel and trade, making it difficult for needed experts and supplies to access the affected areas.

Ebola, WHO
A health care worker from the World Health Organization, left, gives an Ebola vaccination to a front line aid worker who will then vaccinate people who might potentially have the virus, in Mbandaka, Congo. VOA

However, as a precaution, WHO recommended exit screenings, including at airports, ports and land crossings. But it noted that entry screenings, particularly in distant airports, would have no public health benefit and would be costly.

Also Read: North Kivu And Ituri, Congo To Welcome More Than 80,000 Children In This New School Year

WHO advised DRC’s nine neighboring countries that they were at high risk of having the disease spread into their territories, and it said it was supporting them with equipment and personnel. It said these preparedness activities were expensive and would require substantial financial support from the international community. (VOA)

Next Story