Monday February 19, 2018

Grey Matter Volume generally Decrease with Age, its density actually Increases during Adolescence: Study

Grey matter density, a measure often assumed to be highly related to volume, has not been systematically investigated in development

0
//
68
Representative Image, Wikimedia
Republish
Reprint

New York, May 26, 2017: While grey matter volume generally decrease with age, its density actually increases during adolescence, new research has found.

Grey matter is found in regions of the brain responsible for muscle control, sensory perception such as seeing and hearing, memory, emotions, speech, decision-making, and self-control.

For years, the common narrative in human developmental neuro-imaging has been that grey matter in the brain declines in adolescence, a finding derived mainly from studies of grey matter volume and cortical thickness –the thickness of the outer layers of brain that contain grey matter.

NewsGram brings to you latest new stories in India.

Grey matter density, a measure often assumed to be highly related to volume, has not been systematically investigated in development.

Th new study published in the Journal of Neuroscience revealed that while volume indeed decreases from childhood to young adulthood, grey matter density actually increases.

“We now have a richer, fuller concept of what happens during brain development,” said Ruben Gur, Professor at Perelman School of Medicine at the University of Pennsylvania, US.

Since it has been well-established that larger brain volume is associated with better cognitive performance, it was puzzling that cognitive performance shows a dramatic improvement from childhood to young adulthood at the same time that brain volume and cortical thickness decline.

The new findings can help solve this puzzle. The study also showed that while females have lower brain volume, proportionate to their smaller size, they have higher grey matter density than males, which could explain why their cognitive performance is comparable despite having lower brain volume.

Follow NewsGram on Facebook

Thus, while adolescents lose brain volume, and females have lower brain volume than males, this is compensated for by increased density of grey matter.

In the study, the researchers evaluated 1,189 youth between the ages of 8 and 23 who completed magnetic resonance imaging as part of the Philadelphia Neurodevelopmental Cohort, a community-based study of brain development.

The study includes rich neuroimaging and cognitive data, to look at age-related effects on multiple measures of regional grey matter, including gray matter volume, gray matter density, and cortical thickness.

Neuroimaging allowed the researchers to derive several measures of human brain structure in a noninvasive way.

Observing such measures during development allowed the researchers to study the brain at different ages to characterise how a child’s brain differs from an adult’s.

Follow NewsGram on Twitter.

The study may better explain the extent and intensity of changes in mental life and behavior that occur during the transition from childhood to young adulthood.

“If we are puzzled by the behavior of adolescents, it may help to know that they need to adjust to a brain that is changing in its size and composition at the same time that demands on performance and acceptable behavior keep scaling up,” Gur added. (IANS)

Click here for reuse options!
Copyright 2017 NewsGram

Next Story

Novel stroke treatment repairs damaged brain tissue

Researchers have developed a new stem-cell based treatment for stroke that reduces brain damage and accelerates the brain's natural healing tendencies

0
//
14
The new research can reduce the threat of permanent brain damage considerably.
The new research can reduce the threat of permanent brain damage considerably. Wikimedia Commons

Researchers have developed a new stem-cell based treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies.

The treatment called AB126 was developed using extracellular vesicles (EV) — fluid-filled structures known as exosomes — which are generated from human neural stem cells.

“This is truly exciting evidence because exosomes provide a stealth-like characteristic, invisible even to the body’s own defences.

Also Read: Heart Surgery In Infants May Cause Deafness

When packaged with therapeutics, these treatments can actually change cell progression and improve functional recovery,” said Steven Stice, a professor at the University of Georgia in the US who led the research team.

Fully able to cloak itself within the bloodstream, this type of regenerative EV therapy appears to be the most promising in overcoming the limitations of many cells therapies-with the ability for exosomes to carry and deliver multiple doses-as well as the ability to store and administer treatment, the researchers said.

Human clinical trials for the treatment could begin as early as next year, the researchers added.
Human clinical trials for the treatment could begin as early as next year, the researchers added. Wikimedia Commons

Small in size, the tiny tubular shape of an exosome allows EV therapy to cross barriers that cells cannot be said the study published in the journal Translational Stroke Research.

Following the administration of AB126, the researchers used MRI scans to measure brain atrophy rates in preclinical, age-matched stroke models, which showed an approximately 35 percent decrease in the size of injury and 50 percent reduction in brain tissue loss.

Also Read: Father’s Stress Linked To Kids’ Brain Development

“Until now, we had very little evidence specific to neural exosome treatment and the ability to improve motor function. Just days after stroke, we saw better mobility, improved balance and measurable behavioural benefits in treated animal models,” Stice said.

Human clinical trials for the treatment could begin as early as next year, the researchers added. (IANS)