Sunday April 21, 2019

HIV Infected Smokers More likely to die of lung cancer than AIDS, Reveals Indian-origin Researcher

Smoking kills! A recent research reveals a vicious reality about the people infected with HIV, who loves to smoke, are more likely to die from lung cancer than from AIDS.

0
//
lung cancer
Cigarette smoking is injurious to health. Pixabay

New York, September 20, 2017: People living with HIV who adhere to antiretroviral therapy, but smoke tobacco cigarettes are more likely to die from lung cancer than from AIDS, a study led by an Indian-origin researcher has revealed.

The findings showed that overall people with HIV who take antiviral medicines, but who also smoke are six to 13 times more likely to die from lung cancer than from HIV/AIDS, depending on the intensity of smoking and their sex.

“Smoking and HIV are a particularly bad combination when it comes to lung cancer,” said lead author Krishna Reddy, MD, Massachusetts General Hospital (MGH).

“Lung cancer is now one of the leading killers of people with HIV, but most of these deaths can be prevented,” added Rochelle Walensky, Professor at Harvard Medical School.

Among men who continued to be heavy smokers, an estimated 29 percent would die of lung cancer by age 80, as would 23 per cent of moderate smokers and 19 per cent of light smokers.

For women who continued to be heavy smokers, an estimated 29 percent would die of lung cancer by age 80, as would 21 per cent of moderate smokers and 17 per cent of light smokers.

“The data tell us that now is the time for action: smoking cessation programmes should be integrated into HIV care just like antiviral therapy,” Reddy said in the paper published in the journal JAMA Internal Medicine.

However, among those who managed to quit smoking at age 40, only about six per cent die of lung cancer.

“Quitting smoking is one of the most important things that people with HIV can do to improve their health and live longer,” suggested Travis Baggett, Assistant Professor at the Harvard Medical School.

ALSO READ: Cases of Glaucoma show a rising trend in India, can be caused by Smoking: Doctors

Besides reducing the risk of lung cancer, quitting will also decrease their risk of other diseases such as heart attack, stroke and emphysema, the researchers said. (IANS)

 

Next Story

‘Successful’ Treatment: Man Free Of The AIDS Virus After A Stem Cell Ttransplant

Stem cell transplants typically are harsh procedures which start with radiation or chemotherapy to damage the body's existing immune system and make room for a new one.

0
HIV
Shown March 4, 2019, in Seattle, Timothy Brown is the first person to be cured of HIV infection, more than a decade ago. Researchers now say a second patient has lived 18 months after stopping HIV treatment without sign of the virus following a stem-cell transplant. VOA

A London man appears to be free of the AIDS virus after a stem cell transplant, the second success including the “Berlin patient,” doctors reported.

The therapy had an early success with Timothy Ray Brown, a U.S. man treated in Germany who is 12 years post-transplant and still free of HIV. Until now, Brown is the only person thought to have been cured of infection with HIV, the virus that causes AIDS.

 

The latest case “shows the cure of Timothy Brown was not a fluke and can be recreated,” said Dr. Keith Jerome of Fred Hutchinson Cancer Research Center in Seattle who had no role. He added that it could lead to a simpler approach that could be used more widely.

The case was published online Monday by the journal Nature and will be presented at an HIV conference in Seattle.

The patient has not been identified. He was diagnosed with HIV in 2003 and started taking drugs to control the infection in 2012. It’s unclear why he waited that long. He developed Hodgkin lymphoma that year and agreed to a stem cell transplant to treat the cancer in 2016.

AIDS
Usually, HIV patients expect to stay on daily pills for life to suppress the virus. When drugs are stopped, the virus roars back, usually in two to three weeks. VOA

With the right kind of donor, his doctors figured, the London patient might get a bonus beyond treating his cancer: a possible HIV cure.

Doctors found a donor with a gene mutation that confers natural resistance to HIV. About 1 percent of people descended from northern Europeans have inherited the mutation from both parents and are immune to most HIV. The donor had this double copy of the mutation.

That was “an improbable event,” said lead researcher Ravindra Gupta of University College London. “That’s why this has not been observed more frequently.”

The transplant changed the London patient’s immune system, giving him the donor’s mutation and HIV resistance.
The patient voluntarily stopped taking HIV drugs to see if the virus would come back.

Usually, HIV patients expect to stay on daily pills for life to suppress the virus. When drugs are stopped, the virus roars back, usually in two to three weeks.

Drugs
The patient has not been identified. He was diagnosed with HIV in 2003 and started taking drugs to control the infection in 2012. VOA

That didn’t happen with the London patient. There is still no trace of the virus after 18 months off the drugs.

Brown said he would like to meet the London patient and would encourage him to go public because “it’s been very useful for science and for giving hope to HIV-positive people, to people living with HIV,” he told The Associated Press Monday.

Stem cell transplants typically are harsh procedures which start with radiation or chemotherapy to damage the body’s existing immune system and make room for a new one. There are complications too. Brown had to have a second stem cell transplant when his leukemia returned.

Also Read: Air-polluted Cities On Increase In Asia, Coal Addiction Puts Chokehold

Compared to Brown, the London patient had a less punishing form of chemotherapy to get ready for the transplant, didn’t have radiation and had only a mild reaction to the transplant.

Dr. Gero Hutter, the German doctor who treated Brown, called the new case “great news” and “one piece in the HIV cure puzzle.” (VOA)