Never miss a story

Get subscribed to our newsletter

Tuberculosis each year exceeds deaths caused by malaria. Unsplash

Researchers in Microbiology and Cell Biology of the country’s premier research institute, the Indian Institute of Sciences (IISc) have found a new, faster, and more efficient way to detect whether a person has active Tuberculosis (TB) by using their immune response to certain proteins unique to the TB bacilli. The new research was published in the Clinical Infectious Diseases journal published by Oxford University Press, London in its latest edition.

Tuberculosis each year exceeds deaths caused by malaria, AIDS, and all tropical diseases combined, making tuberculosis the world’s single largest killer. Tuberculosis (TB), particularly in forms that affect body parts other than the lungs, can be tricky to diagnose.
Researchers led by S. Vijaya in the Department of Microbiology and Cell Biology have found a new, faster, and more efficient way to use a person’s immune response to certain proteins unique to the TB bacilli to detect whether they have active TB.

Follow NewsGram on LinkedIn to know what’s happening around the world.

The team has discovered that active TB can be diagnosed if blood samples have immune cells with the following signature – having the biochemicals CD38 and CD4 but lacking CD27 while releasing a messenger molecule called Tumor Necrotic Factor (TNF-a).

“Immune cells in our blood have different sets of molecules on their surface – proteins, sugars, small compounds – depending on whether they are inactive as in healthy people, fighting a current infection, or remembering a past infection. The presence or absence of a certain unique combination of such molecules (called a biomarker) makes it possible to detect current disease in the body.

Active TB can be diagnosed if blood samples have immune cells. Unsplash

Biomarkers are used by our organs and immune system to check and react to foreign particles, allergens, and most importantly, harmful microorganisms,” the paper explained. In their experiments, the research team added TB antigens to a blood sample to trigger an immune reaction. Analyzing the presence or absence of marker proteins on T cells of the blood sample later using a method called flow cytometry, it was possible to accurately diagnose tuberculosis.

ALSO READ: Blood Protein Test Can Detect Head Trauma in 15 Minutes

The early and accurate diagnosis followed by timely treatment is the key prerequisite to fight tuberculosis (TB) and reduce its global burden. Despite scientific advances, the rapid and correct diagnosis of both pulmonary and extrapulmonary tuberculosis remains a challenge due to traditional reliance on detection of the elusive bacilli, the researchers claimed.

The paper said that Mycobacterium tuberculosis (Mtb)-specific host immune activation and cytokine production have shown significant promise as alternative means of detecting and distinguishing active disease from latent infection. The diagnostic ability of phenotypic markers on Mtb-specific cytokine-producing immune cell subsets for identifying active tuberculosis. In a country like India where TB is endemic, several people have been infected and carry immune cells specific to this organism, making it difficult to distinguish infection from disease. words. (IANS/SP)


Kishu Inu and Dogelon Mars are some of the more popular canine coins in recent months. Their popularity is demonstrated by the vast amount of trading volume that these cryptocurrencies receive.

At the time of writing, Kishu Inu has a trading volume exceeding $10 million and Dogelon Mars has an even larger trading volume that surpasses $30 million.

Keep Reading Show less

HUH Token

It’s here, and it appears that there ain’t nothin’ or no one stopping the skyrocketing force of HUH Token and the release of the long-awaited White Paper is finally here and we’re living for it.

It’s also great to note that Shiba Inu made a triumphant crypto market return this week and the reign of the dog continues though with HUH Token’s White Paper release it could see the ‘Utimeme’ token break out of the atmosphere on its December 6th launch and surpass Shiba Inu for altcoin supremacy.

Keep Reading Show less

HUH Token

HUH Token has been on the lips of crypto lovers for some time now and the much-anticipated White Paper release is here, right now, today!

Not only this but Shiba Inu’s mastery of the altcoin world could be coming to an end on HUH Token’s December 6th release if the aims, goals and technology in the White Paper are anything to go by.

Keep reading... Show less