Sunday July 22, 2018

India has one of highest rates of antibiotic resistance

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Kolkata: India has one of the highest rates of antibiotic resistance in the world, said a recent report, stressing on limiting the use of antibiotics through improved water, sanitation and immunisation.

Titled ‘The State of World Antibiotics 2015’, the study conducted by Centre for Disease Dynamics, Economics and Policy (CDDEP), New Delhi, also shows that in 2010, India was the largest consumer of antibiotics ahead of China and the US.

“MRSA (Methicillin-resistant Staphylococcus aureus) resistance rates have remained high in India. Carbapenem resistance has been increasing overtime. Overall, India has one of the highest rates of antibiotic resistance in the world,” Ramanan Laxminarayan, director, CDDEP, and a lead author of the study told IANS on Thursday.

MRSA is a common pathogen responsible for skin and soft tissue infections, severe bloodstream infections, and pneumonia. Carbapenems are considered last-resort antibiotics, used for infections that are resistant to first-, second- and even third-line antibiotics.

The countries consuming the most antibiotics overall in 2010 were India (13 billion Standard Unit (SU)), China (10 billion SU) and the US, (7 billion SU), according to the study.

In terms of human use of antibiotics, the report said the highest rates of increase are in middle-income countries, particularly the BRICS, a trend that is likely to continue as incomes continue to rise.

“BRICS had the greatest upsurge in antibiotic use from 2000 through 2010:68 percent in Brazil, 19 percent in Russia, 66 percent in India, 37 percent in China, and 219 percent in South Africa,” the report said.

Explaining the trends further, Laxminarayan said the increased demand for animal protein and resulting intensification of food animal production is leading to greater use of antibiotics in agriculture, again driving resistance.

“In India, the use of antibiotics in pre-mixed feed for livestock is going up a lot. We are not even aware that antibiotics are going inside our system. The strategy would be to stop use of antibiotics in the pre-mixed feed,” Laxminarayan, also associated with Public Health Foundation of India, elaborated.

Though the Indian Council of Medical Research began setting up the Anti-Microbial Resistance Surveillance Network in 2011, Laxminarayan said surveillance alone is not enough. The key is preventing intake of antibiotics in cases where they are not needed.

“The first step would be to not purchase antibiotics over the counter without a doctor’s prescription. Doctors should also exercise caution while prescribing them,” he said.

(IANS)

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Why Exercise on Empty Stomach May be Better for Your Health

This is the first study to show that feeding prior to acute exercise affects post-exercise adipose tissue gene expression

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The study analysed effects of eating versus fasting on gene expression in adipose (fat) tissue in response to exercise. Pixabay

If you have been wondering whether it is better to eat or fast before a workout, researchers now have an answer. A new study has found that exercise on empty stomach is better for your health in the long term.

The study analysed effects of eating versus fasting on gene expression in adipose (fat) tissue in response to exercise.

After eating, adipose tissue “is busy responding to the meal and a bout of exercise at this time will not stimulate the same (beneficial) changes in adipose tissue”, explained corresponding author of the study Dylan Thompson from University of Bath in Britain.

“This means that exercise in a fasted state might provoke more favourable changes in adipose tissue, and this could be beneficial for health in the long term,” Thompson added.

“We propose that feeding is likely to blunt long-term adipose tissue adaptation to regular exercise,” the researchers noted in the study published in the American Journal of Physiology — Endocrinology and Metabolism.

The study participants were a group of overweight males who walked for 60 minutes at 60 per cent maximum oxygen consumption on an empty stomach and, on another occasion, two hours after consuming a high-calorie carbohydrate-rich breakfast.

The research team took multiple blood samples after eating or fasting and after exercising.

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Representational image. Pixabay

The researchers also collected fat tissue samples immediately before and one hour after walking.

Gene expression in the adipose tissue differed significantly in the two trials.

The expression of two genes, PDK4 and HSL, increased when the men fasted and exercised and decreased when they ate before exercising.

The rise in PDK4 likely indicates that stored fat was used to fuel metabolism during exercise instead of carbohydrates from the recent meal.

Also Read: Even Light Exercises Have Health Benefits

HSL typically increases when adipose tissue uses stored energy to support increased activity, such as during exercise, Thompson said.

These results reinforce the view that “adipose tissue often faces competing challenges,” Thompson wrote.

“This is the first study to show that feeding prior to acute exercise affects post-exercise adipose tissue gene expression,” the study said. (Bollywood Country)