Thursday November 23, 2017

India tops in development of Stem cell treatment, also it can be a pathbreaking Therapy for Diabetes, Autism

Stem cell therapy has turned out to be a ray of hope for most patients who are trying to find a cure for incurable diseases

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Doctors operating on a patient (representational image), Pixabay

Jan 18, 2017: Stem cell therapy has turned out to be a ray of hope for most patients who are trying to find a cure for incurable diseases. Researchers and experts believe India has been at the top in the development of stem cell treatment followed by several other countries like China and Japan. However, due to lack of awareness, most people don’t think of stem cell therapy as an option for treating most of the incurable diseases.

One of the major issues that India is battling is increasing incidence of diabetes and autism. According to reports, more than 10 million children in India suffer from autism. About 1 to 1.5 per cent of such children are aged 2-9. Autism by far is a mental condition which is present from early childhood, characterised by great difficulty in communicating and forming relationships with other people and in using language and abstract concepts, and also characterised by weakened social interface, weakened communication and indulging in repetitive behaviour.

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In the case of diabetes, it is one of the most talked-about diseases across the world and especially in India, but awareness on this is still low. Diabetes generally occurs due to failure or damage of the cells that produce insulin in the pancreas called Beta cells. Diabetes can be classified into 2 types: Type 1 (T1DM) and Type 2 (T2DM).

Stem cells are part of the human body and have the unique ability of naturally finding and repairing the place of damage within. Over the past two decades, it has been made possible to treat T1DM by transplanting islet cells or even whole pancreas from cadaveric donors (allogenic transplantation). Transplants can enable the body to regain control of blood sugar levels so that insulin injections are no longer needed.

Islet transplantations are not very common, because whole pancreas transplants involve major surgery and carry significant risk. Transplants require the immune system to be suppressed so that the new “alien” organ is not rejected. Immuno-suppressant drugs leave the recipient vulnerable to infections and often have side-effects. One of the biggest problems faced by islet transplantation is the lack of donors.

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This can be overcome by using patient’s own stem cells (autologous transplantation), bypassing all the complications, rejections and side-effects. Research has shown that stem cells present in the patient’s pancreas are able to make new Beta cells. Beta cell progenitors have been found in the pancreas of both rodents and humans; it may be possible to grow islet cells from patient’s existing islet cells. Alternately, mesenchymal stem cells (MSCs) treatment is also being explored. These can be sourced from the patient’s own adipose tissue (fat), umbilical cord, menstrual fluid, bone marrow and the like.

Clinical trials inserting MSCs into Type 1 diabetes patients take advantage of two properties of these cells. Firstly, they have the regenerative potential to repair Beta cells and, secondly, they can modulate the immune system by inhibiting the responses that lead to the auto-immune attack on pancreatic Beta cells. Since these stem cells come from the patient’s own body, there is also no risk of rejection or side-effects. MSCs may be injected intravenously or within the pancreas itself. This approach promotes Beta cell function, thereby reducing or eliminating the requirement for exogenous insulin.

The central government is also planning to curb the growing incidence of diabetes by stringent measures, including higher taxes and stricter advertisement norms to regulate sale of sugar-sweetened beverages and junk food.

Clinical trials are also under way for autism. Experts believe the umbilical cord stem cells are ideal for treating this because they allow doctors to administer uniform doses as they don’t require collection of stem cells from the patient considering it could be a laborious process for child and the parent. Because they are collected right after birth, umbilical cord-derived cells are much more potent than their “older” counterparts like bone marrow-derived cells.

With trials under way, stem cell therapy could be an effective solution in treating autism and Type 1 diabetes rather than harmful drugs. (IANS)

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Intake of Coffee can Reduce the risk of Death for Kidney Patients

Drinking Coffee may increase the lifespan of patients with chronic kidney disease.

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Drinking Coffee reduces mortality in Kidney patients
Drinking Coffee reduces mortality in Kidney patients. Pixabay
  • Want to live longer? Charge up on your cup of coffee. According to a study, caffeine consumption may prolong the lifespan of patients with chronic kidney disease (CKD).

Drinking coffee can Reduce mortality 

The findings showed a dose-dependent inverse association between caffeine and all-cause mortality.

People who had the highest intake of coffee had 24 percent lower risks of dying, while those in the second, third quartile of caffeine consumption had 12 percent and 22 percent lower risk.

“These results suggest that advising patients with CKD to drink more caffeine may reduce their mortality. This would represent a simple, clinically beneficial, and inexpensive option,” said Miguel Bigotte Vieira from Centro Hospitalar Lisboa Norte, in Portugal.

However, “this benefit should ideally be confirmed in a randomised clinical trial”, Vieira added.

For the study, the team examined the association of caffeine consumption with mortality among 2328 patients with CKD. The results will be presented at the ongoing ASN Kidney Week 2017 in New Orleans.

Moreover, this observational study cannot prove that drinking coffee reduces the risk of death in patients with CKD, but only suggests the possibility of such a protective effect, Vieira stressed.

Drinking coffee can also reduce diabetes risk, revealed a reported in the American Chemical Society Journal of Natural Products.(IANS)

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Health Benefits of eating more Whole Grains

Having a whole grain diet helps lose weight, as compared to refined grains -- rich in starch, gluten and devoid of natural fiber.

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Whole grains
Whole grains.Pixabay
  • Regularly consuming whole grain foods such as barley, brown rice, millet, oatmeal and rye may help lose weight
  • It also decreases the risk of heart disease and diabetes, a study has claimed.

Why should you eat more whole grains? Here is all you need to know

The findings showed that study participants who ate whole grains had less inflammation, particularly in overweight people, which increases the risk of developing Type 2 diabetes.

Further, participants were also found to eat less when whole grain products were on the menu because whole grain consumption causes satiety.

Importantly, having a whole grain diet helps lose weight, as compared to refined grains — rich in starch, gluten and devoid of natural fiber.

“Our analysis confirmed that there is a sound scientific basis for the dietary recommendation to eat whole grains. This may particularly apply to people who are at increased risk of developing cardiovascular disease or Type 2 diabetes,” said Tine Rask Licht, professor at the Technical University of Denmark.

Additionally, the researchers used DNA sequencing to analyze stool samples from the participants in order to examine whether the different diet types affected the participants’ gut bacteria composition.

Overall, the analysis did not show major effects of the dietary grain products on the composition of the lose weight.

“However, even though the analysis did not reveal significant changes in the average gut microbiota after whole grain consumption, it may well be that the individual components of our gut microbes has an impact on the individual reaction of our body to dietary whole grains,” Licht explained.

For the study, described in the journal Gut, the team included adults at risk of developing cardiovascular disease or Type 2 diabetes. The participants were divided randomly into two groups, with whole grain diet and refined varieties for eight weeks.(IANS)

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Are you suffering from Diabetes? Include these Fruits for your Diabetic Diet Plan

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Diabetes or diabetes mellitus occurs when the pancreas does not secrete enough insulin or when our cells become irresponsive to insulin. This results in the increase in blood glucose or blood sugar levels in your body.

  • A chronic disease like diabetes requires a strict diabetic diet with no cheat days.
  • The per day calorie intake ranges between 1500 to 1800 calories.
  • A diabetic diet plan should have at least three vegetables and two fruits per day. 

Include these relishing healthy fruits in your regular diabetic diet to maintain and treat your diabetes in a way which gives you essential balance in your taste.

Pomegranates

Diabetic Diet
Pomegranates are healthy for treating diabetes. Pixabay.

Acting as antioxidants, pomegranates serve as the best antidote for curing several chronic diseases. Pomegranate juice also helps to reduce the risk of cardiovascular diseases. The tiny red titbits should be added in your diabetic diet to maintain your blood circulation and blood sugar level.

Watermelon

Diabetic Diet
Add Watermelons in your diabetic diet to have a healthy heart. Pixabay.

The sugar content in watermelon is at a moderate level. It helps achieve a healthy combined mix of sugar and hydration if taken in controlled portions. It has a high water content, minerals, and fiber that will reduce your hunger by filling up your stomach with the required amount of water and sugar intake. To avoid overeating, you may add watermelon in your diabetic diet plan.

Strawberries

Diabetic Diet
Strawberries must form a major part of your diabetic diet. Pixabay.

Strawberries are a rich source of vitamin C, fibers, folate and manganese which must form a major part of your diabetic diet plan. They attain a low glycemic level that lowers the rate of release of blood glucose and maintains normal blood sugar level. It enhances immunity against diseases like cancer by increasing metabolism.

Kiwi

Diabetic diet
Eat kiwi and strawberry salad to have a healthy diabetic diet. Pixabay.

Kiwis also have a low glycemic level that does not increase the blood sugar level to a high extent. These are full of vitamin c and fibers that are capable of getting digested slowly. To maintain a healthy diabetic diet, kiwi’s would be beneficial to satisfy your tongue.

Apples

Diabetic diet
Apples in your diabetic diet will help you treat type 2 diabetes. Pixabay.

Undoubtedly, An apple a day keeps the doctor away. Apples are antioxidants filled with fibers that can treat diabetes in the best way. Apples are used to treat the risk of type 2 diabetes and should be counted up in your diabetic diet plan.

-Prepared by Bhavana Rathi of NewsGram. Twitter @tweet_bhavana