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Kidney Problems and even Dementia, for People who have Protein in their Urine: Study

Chronic kidney disease and dementia share many risk factors, such as high blood pressure, diabetes and high cholesterol

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Human Urine sample. Wikimedia

London, December 15, 2016: People who have protein in their urine — a marker of kidney problems — could also be at higher risk of developing problems with thinking and memory skills or even dementia, a study has found.

“Kidney dysfunction has been considered a possible risk factor for cognitive impairment or dementia,” said Kay Deckers from Maastricht University in the Netherlands.

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The analysis showed that people with protein — also known as called albuminuria or proteinuria — in the urine were 35 per cent more likely to develop cognitive impairment or dementia than people who did not have protein in their urine.

“Protein in the urine was associated with a modestly increased risk of cognitive impairment or dementia,” Deckers said.

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“Chronic kidney disease and dementia share many risk factors, such as high blood pressure, diabetes and high cholesterol, and both show similar effects on the brain, so they may have shared vascular factors or there may even be a direct effect on the brain from kidney problems,” he added.

In addition to analysis on albuminuria or proteinuria, the team also observed other markers of kidney function, known as glomerular filtration rate — best test to measure your level of kidney function and determine stage of kidney disease.

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The results were found to be mixed and did not show an association with cognitive impairment or dementia.

For the study, published online in the journal Neurology, the team conducted a meta-analysis of 22 studies on the topic, including 27,805 people. (IANS)

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Distress May Spike up Risk of Dementia

For the study, the team included 6,807 Danish participants aged 60 years on average

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Extreme distress increases risk for dementia: Study. Pixabay

Men and women who are distressed in midlife could be at higher risk of developing dementia in their old age, suggests a new study.

The study showed that vital exhaustion, which can be perceived as an indicator of psychological distress, is a risk factor for future risk of dementia.

Psychological distress is potentially linked to the risk of dementia through neurological and cardiovascular mechanisms.

The findings, led by researchers from the University of Copenhagen in Denmark, revealed that for each additional symptom of vital exhaustion, the risk of dementia rose by two per cent.

While participants reporting five to nine symptoms had a 25 per cent higher risk of dementia than those with no symptoms, those reporting 10 to 17 symptoms had a 40 per cent higher risk of dementia compared with not having symptoms.

However, the researchers are yet not aware of "exactly how anticholinergics might cause dementia", the researchers said.
Representational Image- dementia, Pixabay

Importantly, physiological stress response, including cardiovascular changes and excessive production of cortisol over a prolonged period, may also contribute to linking psychological distress with an increased risk of dementia, revealed the study published in the Journal of Alzheimer’s Disease.

“Stress can have severe and harmful consequences not just for our brain health, but our health in general. Cardiovascular risk factors are well-known modifiable risk factors for dementia, and in some countries, a stagnation or even a decreasing incidence of dementia has been observed,” said Sabrina Islamoska, postdoctoral student from the varsity.

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For the study, the team included 6,807 Danish participants aged 60 years on average.

Psychological distress is an important risk factor that should receive more focus when considering prevention initiatives in relation to later dementia, the team said. (IANS)