Thursday July 19, 2018
Home India May 13 is Ron...

May 13 is Ronald Ross’ 160th Birth Anniversary: Finding the course of Dreaded Disease ‘Malaria’ – for 8 Annas

0
//
92
Ronald Ross, Wikimedia
Republish
Reprint

May 13, 2017: Affecting humans across all continents for centuries, this debilitating disease was long believed to be caused by unhealthy vapours, which gave its name – malaria (from Latin for bad air). While several scientists in the 19th century began zeroing in on its actual cause, the definitive proof was obtained by a British doctor in India who paid a volunteer eight annas for being bitten the same number of times by the suspected vector.

And Ronald Ross, who would be knighted and win the second Noble Prize for Medicine (not without controversy), celebrated his discovery by writing a poem to his wife – ending “I know this little thing/A myriad men will save/O Death, where is thy sting? Thy victory, O Grave?” (the last lines a reworking of the hymn “Abide With Me”).

NewsGram brings to you current foreign news from all over the world.

Though the discovery in August 1897 was built on work of many scientists around the world since the beginning of the century, Ross (1857-1932), whose 160th birth anniversary is on Saturday (May 13), was also a mathematician, novelist, dramatist, poet, amateur musician, composer and artist though it is as a persistent — and impulsive medical researcher he is most famous.

Born in Almora in the family of a British general, he studied in Britain where he proved to be exceptionally good in mathematics and wanted to be a writer but was admitted to St Bartholomew’s Hospital Medical College by his father in 1874.

NewsGram brings to you top news around the world today.

Though he spent most of his time writing poems and plays, he did pass his examinations to become a surgeon in 1880. He entered the Indian Medical Service in 1881 and was posted to various areas including Madras, Bangalore (where in 1883 he noticed mosquitoes could be controlled by limiting their access to water and suffered from malaria himself), Baluchistan and even the Andaman Islands.

His interest in malaria was sparked by a meeting with Sir Patrick Manson, the “father of tropical medicine”, during a spell of leave in London in 1894 and they discussed findings of Charles Laveran, a French army surgeon in Algeria who had discovered parasitical cells in the blood of a patient.

It was in Secundrabad, where he was posted in 1895, that Ross began his research to ascertain whether mosquitoes transmitted malaria parasites, but for years, made no headway.

Check out NewsGram for latest international news updates.

“Eventually in July 1897 he reared 20 adult ‘brown’ mosquitoes from collected larvae. Following identification of a volunteer (Husein Khan) infected with crescents of malignant tertian malaria and the expenditure of 8 annas (one anna per blood-fed mosquito!), Ross embarked on a four-day study of the resultant engorged insects. This ‘compact’ study was written up and submitted for publication.

“Imagine today sending an article to a leading medical journal ‘in which you describe observations on novel objects found on the midguts of just two ‘brown’ mosquitoes, obtained from larvae of natural origin, that you had previously fed on a naturally infected patient – with no appropriate controls and no replicates! What hope would it have of getting past the editor and reviewers,” asked Robert Sinden in an article on Ross and his discovery in the January 2014 bulletin of the World Health Organisation.

Sinden, of the Faculty of Natural Sciences in London’s Imperial College, however goes on to say that despite the “perceived inadequacies of the study design, it is difficult to overstate the importance of Ross’s paper: the award of a Nobel Prize hardly does justice to the subsequent impact of his conclusions”, especially in identifying the most vulnerable stage in the parasite’s lifecycle for effective intervention.

But that was not the limit of Ross’ contribution to fighting this — or other dreaded diseases.

Before resigning from the IMS in 1899 after trying unsuccessfully to find the cause of kala azar in eastern India, he subsequently joined the Liverpool School of Tropical Medicine and continued to work on prevention of malaria in different parts of the world. He also developed mathematical models for the study of malaria epidemiology.

Ross, who won the Nobel in 1902 (after a tussle with Italian researchers who had also identified the cause in 1897), went on to set up the Ross Institute and Hospital for Tropical Diseases in 1926 which he headed till his death.

But despite his path-breaking work, malaria, which due to its high mortality and morbidity levels, has had the greatest selective pressure on the human genome in recent history, still exerts its malignant effect across some of the world’s poorest regions — though some hope lies in a vaccine due to be tested in Africa the next year. (IANS)

Click here for reuse options!
Copyright 2017 NewsGram

Next Story

Brian Gitta: A Malaria Test That Would Not Need Blood Samples

The new malaria test kit works by shining a red beam of light onto a finger

0
A health service worker takes a blood sample for a malaria test in Dajabon, Dominican Republic, on the border with Haiti, Oct. 6, 2009. A test that doesn't require a needle or blood has won the Africa Prize for Engineering Innovation
A health service worker takes a blood sample for a malaria test in Dajabon, Dominican Republic, on the border with Haiti, Oct. 6, 2009. A test that doesn't require a needle or blood has won the Africa Prize for Engineering Innovation, VOA

Languishing with fever and frustrated by delays in diagnosing his illness, Brian Gitta came up with a bright idea: a malaria test that would not need blood samples or specialized laboratory technicians.

That inspiration has won the 25-year-old Ugandan computer scientist a prestigious engineering prize for a noninvasive malaria test kit that he hopes will be widely used across Africa.

For developing the reusable test kit known as Matibabu, Gitta this month was awarded the Africa Prize for Engineering Innovation. The award by the Royal Academy of Engineering in Britain comes with $32,940.

Malaria is the biggest killer in Africa, and the sub-Saharan region accounts for about 80 percent of the world’s malaria cases and deaths. Cases rose to 216 million in 2016, up from 211 million cases in 2015, according to the latest World Malaria Report, released late last year. Malaria deaths fell by 1,000, to 445,000.

The mosquito-borne disease is a challenge to prevent, with increasing resistance reported to both drugs and insecticides.

No needles

The new malaria test kit works by shining a red beam of light onto a finger to detect changes in the shape, color and concentration of red blood cells, all of which are affected by malaria. The results are sent within a minute to a computer or mobile phone linked to the device.

A Portugal-based firm has been contracted to produce the components for Matibabu, the Swahili word for “treatment.”

“It’s a perfect example of how engineering can unlock development, in this case by improving health care,” Rebecca Enonchong, Africa Prize for Engineering Innovation judge, said in a statement. “Matibabu is simply a game changer.”

A woman carrying a baby holds a treated mosquito net during a malaria prevention action at Ajah in Eti Osa East district of Lagos, Nigeria, April 21, 2016.
A woman carrying a baby holds a treated mosquito net during a malaria prevention action at Ajah in Eti Osa East district of Lagos, Nigeria, April 21, 2016. VOA

Gitta and five colleagues, all trained in computer science or engineering, developed an affordable, bloodless test that does not need a specialist to operate. The new test will be suitable for use in Africa’s rural areas, where most cases of malaria occur, because it will not depend on sending blood samples to a distant laboratory.

Others are also working to fill the need for quicker, easier malaria tests. There are more than 200 rapid diagnostic test products for malaria on the market, according to the WHO.

80 percent accurate now

The fifth-generation prototype of Matibabu, with an accuracy rate of 80 percent, is still a work in process. Gitta and his group aim to refine the device until it achieves an accuracy rate exceeding 90 percent.

Matibabu has yet to be formally subjected to all the necessary clinical trials under Ugandan safety and ethics regulations.

“It excites me as a clinician,” said Medard Bitekyerezo, a Ugandan physician who chairs the National Drug Authority. “I think the National Drug Authority will approve it.”

The government should invest in the project so that its developers don’t struggle financially, he added. The unit cost of the latest prototype is about $100.

Despite the optimism, Gitta has found a hurdle he didn’t anticipate: Some patients are skeptical of unfamiliar technology.

“The doctors will tell you that some people will not leave the hospital until their children have been pricked, and until they have been given anti-malaria drugs and painkillers, even if the kid is not sick,” he said.

Also read: From Radio Signals A Pill Could Tell About Gut Health And Help Doctors

“We think we are developing for hospitals first, so that people can first get attached to the brand, and gain the trust of patients over time.” (VOA)