Wednesday January 24, 2018

More Sexual Partners Doubles the Risk of Developing Prostate Cancer: Study

According to a recent study, the risk of prosate cancer is doubled by multiple sexual partners

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FILE - A biotechnician demonstrates the loading of a genome sequencing machine at the J. Craig Venter Institute in Rockville, Maryland. Relative to their ability to pay, cancer patients in China and India face much higher prices than wealthier U.S. patients. VOA
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Sydney, Nov 22, 2016: The more sexual partners a man has may double his risk of developing prostate cancer, a study has claimed.

The study found that men who had more than seven sexual partners in their lifetime were twice as likely to have prostate cancer than those with fewer than three partners.

Men who are sexually active earlier may also be a risk, the researchers said.

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“The more partners you had, the more orgasms you had, the younger you were when you first had sex, all pointed to an increased prostate cancer risk,” Visalini Nair-Shalliker, doctoral student at Cancer Council New South Wales in Australia, was quoted as saying to smh.com.au.

It’s believed this increased risk associated with sexual activity could be due to hormonal changes.

Sexual activity and metabolism were associated with antigen, a male sex hormone that is also strongly linked to the initiation of prostate cancer.

Other risk factors included having a father with a history of prostate cancer, a previous diagnosis of prostatitis or benign prostatic hyperplasia.

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In addition, the study found that being overweight or obese was also associated with increased risk of the disease, but to a lesser extent.

There was no association found between prostate cancer risk and circumcision, vasectomy or erectile function, the researchers observed.

It is important to identify risk factors so men could be given advice, and men aged over 50 who fell into those risk categories should speak to their doctors, especially if they had a family history of the disease, Nair-Shalliker said.

However, “we can’t make any recommendations around sexual activity because it’s multi-faceted. We’re not saying ‘increase or decrease your sexual activity’ because the evidence is still grey about that,” Nair-Shalliker noted, in the paper published in the journal in the International Journal of Cancer. (IANS)

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A tool which can predict cancer

Researchers develop a tool to predict cancer in men

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Researchers developed a tool which can predict cancer in men. Pixabay
Researchers developed a tool which can predict cancer in men. Pixabay
  • A tool has been developed for predicting the onset of prostate cancer in men.
  • Score from a PSA test is very versatile and can be applied to many age related diseases.
  • This study was published in journal BMJ.

A genetic prognostic tool has been developed by a team of researchers that may help in predicting the age of onset of prostate cancer in men.

Polygenic hazard score is intended to inform men whether to undergo Prostate-Specific Antigen (PSA) Test. The score can be calculated at any time since an individual’s genotype does not change.

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How the score works

The score involves survival analysis to estimate the effect of individual genomes for small variations, called single-nucleotide polymorphisms (SNPs), on age at diagnosis of aggressive prostate cancer.

This is especially critical for men at risk of developing prostate cancer at a very young age before standard guidelines recommend consideration of screening.

Prostrate cancer is one of the most common in men. Pixabay
Prostate cancer is one of the most common in men. Pixabay

“The polygenic hazard score is very versatile and can be applied to many age-related diseases,” said Chun Chieh Fan, from the University of California – San Diego.

Also read: Pregnancy seems Safe for Breast Cancer Survivors: Study

“In this case, the polygenic hazard score of prostate cancer captures the age variations of aggressive prostate cancer.”

The score has already been proven to be very useful in predicting the age of onset for Alzheimer’s disease, the researchers said.

Other than prostate cancer, lung cancer is most common amongst men. Pixabay
Other than prostate cancer, lung cancer is most common amongst men. Pixabay

How it was done

When men with a high polygenic hazard score were compared to those with average polygenic hazard score, their risk of aggressive prostate cancer was at least 2.9 times greater, the researchers said, adding that this kind of genetic risk stratification is a step toward individualised medicine.

Further, PSA tests are much more predictive of aggressive prostate cancer in men with high polygenic hazard score than in those with low polygenic hazard score. This suggests that the score can help physicians determine whether to order a PSA test for a given patient.

The study was published in journal BMJ. (IANS)