Neem extract can be used in pancreatic cancer treatment

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To buy a Neem toothpaste, click here.

New York: Indian-origin scientists and a team of researchers said, a natural extract derived from Neem tree can be used for treating lethal pancreatic cancer.

The results revealed that nimbolide, an active molecule isolated from Neem tree (Azadirachta indica), can stop pancreatic cancer’s growth and spread without harming normal, healthy cells.

“The promise nimbolide has shown is amazing, and the specificity of the treatment towards cancer cells over normal cells is very intriguing,” said Rajkumar Lakshmanaswamy, associate professor at Texas Tech University Health Sciences Center El Paso in the US.

Pancreatic cancer has the highest mortality rate of all cancers with 94 percent of patients dying within five years of diagnosis.

The cancer grows quickly and there are currently no effective treatments available.

In the study, Lakshmanaswamy and colleagues observed that nimbolide was able to reduce the migration and invasion capabilities of pancreatic cancer cells by 70 percent meaning the cancerous cells did not become aggressive and spread.

And that is promising, the researchers said.

In humans, this migration and invasion or metastasis of pancreatic cancer to other regions of the body is the chief cause of mortality.

Nimbolide treatments also induced cancer cell death, causing the size and number of pancreatic cancer cell colonies to drop by 80 percent.

“Nimbolide seems to attack pancreatic cancer from all angles,” Lakshmanaswamy said.

What is more, the Neem compound did not harm healthy cells in both the in vitro and in vivo experiments.

“Many people in India actually eat neem and it doesn’t have harmful side effects, which suggests that using nimbolide for pancreatic cancer will not cause adverse effects like chemotherapy and radiation typically do,” study lead author Ramadevi Subramani, postdoctoral researcher at Texas Tech University Health Sciences Centre, said.

The findings appeared in the journal Scientific Reports.

While the results are promising, Lakshmanaswamy said there is still a long way to go before nimbolide can be used to treat pancreatic cancer in humans.

The researchers said they plan to continue researching the anticancer mechanisms behind the plant extract.(image: stylecraze.com)(IANS)

To buy a Neem toothpaste, click here.

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60% Decrease in Pediatric Fractures During Pandemic: Study

There is a significant decline in sports-related fractures among kids during lockdown

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Children are reporting less sports fractures and injuries during the lockdown, says a recent study. Pixabay

By Siddhi Jain

COVID-19 social distancing measures, including the closure of schools and parks and the indefinite cancellation of team sports, has led to nearly 60 percent decrease in overall in pediatric fractures, according to a new study?.

The study also revealed an increase in the proportion of fractures sustained by children at home. Researchers at Children’s Hospital of Philadelphia (CHOP) found that although the overall rate of fractures is down significantly during the COVID-19 pandemic, the proportion due to bicycle and trampoline injuries has gone up substantially?

The findings, published in the ‘Journal of Pediatric Orthopaedics’, suggest a need for increased awareness of at-home safety measures.

“It is important to remind parents about the importance of basic safety precautions with bicycles and trampolines, as many children are substituting these activities in place of organised sports and school activities,” said Apurva Shah, MD, MBA, an orthopaedic surgeon in CHOP’s Division of Orthopaedics and senior author of the study.

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Researchers found a nearly 2.5-fold decrease in the daily incidence of fractures during the pandemic compared to the pre-pandemic period. Pixabay

The research team gathered data on 1,735 patients who presented at CHOP with acute fractures between March 15 and April 15 and compared that information with patients who presented with fractures during the same timeframe in 2018 and 2019. The researchers found a nearly 2.5-fold decrease in the daily incidence of fracture cases during the pandemic compared to the pre-pandemic period.

Sports-related fractures saw a particularly dramatic decline, accounting for only 7.2 percent of fracture cases during the pandemic versus 26 percent of all fracture cases in the same month in 2018 and 2019.

Despite these significant declines, the researchers found an increase of more than 25 percent in fractures occurring at home, which was accompanied by a 12 percent increase in fractures caused by high-energy falls, like those resulting from trampoline injuries, and bicycle injuries. With families spending more time at home due to social distancing guidelines, the researchers suggest this shift in injury location is a natural result of families finding alternative recreational activities for their children.

Also Read: AirAsia India Provides 50K Free Domestic Flight Tickets to Doctors as Tribute

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Patients aged 12 and over saw a five-fold reduction in the monthly number of fractures. Pixabay

The decline in fracture incidence was bigger for some age groups than others. Patients aged 12 and over saw a five-fold reduction in the monthly number of fracture cases, whereas children aged 5 and under saw only a 1.5-fold decrease.

The researchers surmise this is due to younger children substituting other active pursuits for pre-pandemic activities, like playground outings and other outdoor activities, whereas adolescents, who are more likely to play team sports, are making fewer of those substitutions. (IANS)

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Every 4 in 10 Adults Suffer From Gastrointestinal Disorders Globally: Researchers

Mostly people find it embarrassing to talk about stomach and bowel symptoms

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For every ten adults in the world, four suffer from functional gastrointestinal disorders. Pixabay

For every ten adults in the world, four suffer from functional gastrointestinal disorders of varying severity, say Researchers, adding that people think it’s embarrassing to talk about stomach and bowel symptoms.

Functional gastrointestinal disorders, FGIDs, is a collective term for chronic disorders in the gastrointestinal tract. The symptoms may arise throughout the gastrointestinal tract. From the upper part, the esophagus and stomach, they can include heartburn, acid reflux and indigestion (dyspepsia).For the lower parts (the intestines), chronic constipation, abdominal distension or bloating, and irritable bowel syndrome (IBS) are among the complaints.

The current study, published in the journal Gastroenterology, gives an overall picture of the global prevalence of FGIDs. Data of more than 73,000 people in 33 countries were collected by means of web-based questionnaires and face-to-face (household) interviews.

“It’s striking how similar the findings are between countries. We can see some variations but, in general, these disorders are equally common whatever the country or continent,” said study author Magnus Simren from University of Gothenburg in Sweden.Web-based questionnaires were used in most of the countries in the study.

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The findings showed that the prevalence of FGIDs was higher in women than in men. Piaxbay

In some countries, instead, the respondents were asked to reply to the questions when an interviewer read them aloud.The questions posed to the respondents were based on the diagnostic criteria for IBS and other FGIDs. Particulars of other diseases and symptoms, living conditions, quality of life, healthcare consumption, etc. were also requested.

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The findings showed that the prevalence of FGIDs was higher in women than in men, and clearly associated with lower quality of life. According to the questionnaire responses, 49 per cent of the women and 37 per cent of the men met the diagnostic criteria for at least one FGID. The severity of the disorders varied, from mild discomfort to symptoms that adversely affected the quality of life to a high degree.

The prevalence of FGIDs was also strongly associated with high consumption of healthcare, such as visits to the doctor and use of medication, but also surgery, the study said. (IANS)

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Smoking: Its Ill effects On Fertility and Child Birth

Smoking and tobacco use can have a serious impact on fertility and consequently the quality of life in pregnancy

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Smoking increases miscarriage rates in women. Pixabay

BY SIDDHI JAIN

Smoking and tobacco use can have a serious impact on the fertility of both men and women, and consequently the quality of life in pregnancy. These health tips by expert can help. If a woman is a regular smoker, then it has a double effect on a woman’s fertility. Smoking can harm both the eggs and the uterus. It not only affects her egg quality, but can also have endometrial effect. Many studies too have shown that smoking can have negative effects on fertility, notes Dr Apurva Satish Amarnath, Fertility Consultant, Nova IVF Fertility.

“In women, smoking decreases in vitro fertilization (IVF) and intrauterine insemination (IUI) pregnancy rates by about half. Smoking also increases miscarriage rates. smoking also reduces the egg reserve of the woman which is not a reversible condition. For instance, if we are to compare two women with the same characteristics in terms of egg quality, quantity, BMI, AMH-level, among others, the chances are that the non-smoking woman will conceive faster than the smoking woman. If a woman quits smoking completely, then the chances of conception improve and the risk of miscarriage reduces,” Dr Apurva told IANSlife ahead of the International Anti-Tobacco Day on May 31.

From the male’s perspective, the carcinogen quality of cigarettes in general affects the motility of the sperm and excessive smoking can lead to the poor sperm count and other fertility problems. As compared to females, the condition can be reversible.

If a man completely gives up smoking the quality of his sperms can improve, resulting in his fertility improving in a span of 3-6 months after quitting completely, she said.

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Smoking and tobacco use can have a serious impact on fertility. Pixabay

Smoking during pregnancy

According to Dr Sandeep Chadha, Consultant Obstetrician and Gynecologist at Motherhood Hospital, Noida, smoking during pregnancy are dangerous for both mother and the baby.

If a mother smokes, the 4,000 harmful chemicals present in each cigarette passes directly to the baby through the mother’s bloodstreams. In such cases, the risk of stillbirth and miscarriage goes up besides an increased risk of low birth weight, baby’s heart rate, breathing problem and premature delivery, Dr Sandeep told IANSlife.

These risks to the baby multiply with the number of cigarettes smoked during pregnancy. Not only for babies, but tobacco smoking is also harmful to the mother, increasing her risk of cancers, cardiovascular disease, emphysema, and other conditions.

Passive smoking and childbirth

A study has presented that exposure to secondhand smoke was associated with lower IQs in children. For babies exposed to secondhand smoke, there is an increase in risk for developing asthma attacks, breathing problems, ear infections, impaired lung development, and coughing.

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Smoking tobacco decreases in vitro fertilization (IVF) and intrauterine insemination (IUI) pregnancy rates. Pixabay

Children exposed to secondhand smoke require more ear tube surgeries than those who are not exposed. Sudden infant death syndrome is more common in babies born to women who smoked during pregnancy as well as in babies exposed to secondhand smoke. Exposure to second-hand smoking by pregnant mothers is similar to first hand smoking.

Also Read: Patients of 80% COVID-19 Cases in India Exhibit Nil or Mild Symptoms: Health Minister

If you are planning to conceive, it’s better for the couple to kick the butt as early as possible. (IANS)