Wednesday February 20, 2019

Neem extract can be used in pancreatic cancer treatment

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To buy a Neem toothpaste, click here.

New York: Indian-origin scientists and a team of researchers said, a natural extract derived from Neem tree can be used for treating lethal pancreatic cancer.

The results revealed that nimbolide, an active molecule isolated from Neem tree (Azadirachta indica), can stop pancreatic cancer’s growth and spread without harming normal, healthy cells.

“The promise nimbolide has shown is amazing, and the specificity of the treatment towards cancer cells over normal cells is very intriguing,” said Rajkumar Lakshmanaswamy, associate professor at Texas Tech University Health Sciences Center El Paso in the US.

Pancreatic cancer has the highest mortality rate of all cancers with 94 percent of patients dying within five years of diagnosis.

The cancer grows quickly and there are currently no effective treatments available.

In the study, Lakshmanaswamy and colleagues observed that nimbolide was able to reduce the migration and invasion capabilities of pancreatic cancer cells by 70 percent meaning the cancerous cells did not become aggressive and spread.

And that is promising, the researchers said.

In humans, this migration and invasion or metastasis of pancreatic cancer to other regions of the body is the chief cause of mortality.

Nimbolide treatments also induced cancer cell death, causing the size and number of pancreatic cancer cell colonies to drop by 80 percent.

“Nimbolide seems to attack pancreatic cancer from all angles,” Lakshmanaswamy said.

What is more, the Neem compound did not harm healthy cells in both the in vitro and in vivo experiments.

“Many people in India actually eat neem and it doesn’t have harmful side effects, which suggests that using nimbolide for pancreatic cancer will not cause adverse effects like chemotherapy and radiation typically do,” study lead author Ramadevi Subramani, postdoctoral researcher at Texas Tech University Health Sciences Centre, said.

The findings appeared in the journal Scientific Reports.

While the results are promising, Lakshmanaswamy said there is still a long way to go before nimbolide can be used to treat pancreatic cancer in humans.

The researchers said they plan to continue researching the anticancer mechanisms behind the plant extract.(image: stylecraze.com)(IANS)

To buy a Neem toothpaste, click here.

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Low Cure Rate For Childhood Cancer in India: Experts

On International Childhood Cancer Day, the hospital organised a ‘Sit and Draw competition’ with pediatric patients and rewarded the winner

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Health insurance covers only for hospitalization and doesn’t necessarily cover the medical expenses incurred for the treatment of major illnesses. flickr

Childhood cancer comprises almost 3-5 per cent of the total cancer cases in India, experts said here on Friday, expressing concern over the low cure rate due to lack of available data.

“The disturbing reality is that the cure rate of pediatric cancer is almost 80 per cent in the developed countries. When we see the data from major cancer centres, it actually can match up to the Western standard but this data is not enough,” Haemato-Oncologist Vivek Agarwala said at an awareness programme conducted by Narayana Superspecialty Hospital, Howrah.

According to the Indian Council for Medical Research, cancer in children constitutes approximately 3-5 per cent of the total cancer cases in India.

Agarwala said a large portion of the incidence of childhood cancer in society is still not addressed.

Cancer survivor. Flickr

Also, a large section who don’t have access to premier institutes are often diagnosed late due to financial crunch and that is why the overall treatment rate in India is low.

“Probably, the government and society at large are not considering it a big problem as it is just around 5 per cent. We are always campaigning for breast and cervical cancers,” Agarwala said.

“We must remember this 5 per cent of cancer is majorly curable if given proper treatment,” he said.

Leukaemia and retinoblastoma (a form of cancer where children have a white eye) are the two common forms of cancer in children.

Also Read- Push-ups Can Lower The Risk of Heart Diseases

Talking about awareness and symptoms that parents need to watch out for, he said: “Symptoms are different for different cancers, but children who have cancer have poor growth, poor weight gain and decreased appetite. One must get their children evaluated on seeing these symptoms”.

On International Childhood Cancer Day, the hospital organised a ‘Sit and Draw competition’ with pediatric patients and rewarded the winner. (IANS)