Sunday May 26, 2019

Neem extract can be used in pancreatic cancer treatment

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To buy a Neem toothpaste, click here.

New York: Indian-origin scientists and a team of researchers said, a natural extract derived from Neem tree can be used for treating lethal pancreatic cancer.

The results revealed that nimbolide, an active molecule isolated from Neem tree (Azadirachta indica), can stop pancreatic cancer’s growth and spread without harming normal, healthy cells.

“The promise nimbolide has shown is amazing, and the specificity of the treatment towards cancer cells over normal cells is very intriguing,” said Rajkumar Lakshmanaswamy, associate professor at Texas Tech University Health Sciences Center El Paso in the US.

Pancreatic cancer has the highest mortality rate of all cancers with 94 percent of patients dying within five years of diagnosis.

The cancer grows quickly and there are currently no effective treatments available.

In the study, Lakshmanaswamy and colleagues observed that nimbolide was able to reduce the migration and invasion capabilities of pancreatic cancer cells by 70 percent meaning the cancerous cells did not become aggressive and spread.

And that is promising, the researchers said.

In humans, this migration and invasion or metastasis of pancreatic cancer to other regions of the body is the chief cause of mortality.

Nimbolide treatments also induced cancer cell death, causing the size and number of pancreatic cancer cell colonies to drop by 80 percent.

“Nimbolide seems to attack pancreatic cancer from all angles,” Lakshmanaswamy said.

What is more, the Neem compound did not harm healthy cells in both the in vitro and in vivo experiments.

“Many people in India actually eat neem and it doesn’t have harmful side effects, which suggests that using nimbolide for pancreatic cancer will not cause adverse effects like chemotherapy and radiation typically do,” study lead author Ramadevi Subramani, postdoctoral researcher at Texas Tech University Health Sciences Centre, said.

The findings appeared in the journal Scientific Reports.

While the results are promising, Lakshmanaswamy said there is still a long way to go before nimbolide can be used to treat pancreatic cancer in humans.

The researchers said they plan to continue researching the anticancer mechanisms behind the plant extract.(image: stylecraze.com)(IANS)

To buy a Neem toothpaste, click here.

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Jury Grants $2 Billion to Couple Claiming ‘Glysophate’ in Roundup Weed Killer Caused Cancer

Vietnam said it would stop importing Roundup and other weed killers with the ingredient

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FILE - Containers of Roundup are displayed on a store shelf in San Francisco, Feb. 24, 2019. VOA

For the third time in less than a year, a jury has ruled the main ingredient in a popular weed killer caused cancer in its users. A San Francisco jury Monday awarded more than $2 billion to a couple in their 70s who say glyphosate in Roundup weed killer gave them non-Hodgkin lymphoma.

The couple say they used Roundup for 35 years. Attorneys for the couple say numerous scientific studies show glyphosate led to cancer in both animal and human populations.

The World Health Organization has classified glyphosate as “probably carcinogenic to humans” and last month, Vietnam said it would stop importing Roundup and other weed killers with the ingredient.

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The World Health Organization has classified glyphosate as “probably carcinogenic to humans”. Pixabay

Bayer, Roundup’s manufacturer, argued that hundreds of other scientific tests show glyphosate is safe and that the U.S. Environmental Protection Agency determined that when used as directed, glyphosate is not dangerous.

ALSO READ: ‘Canine Brucellosis’- A Dog Disease which can Hit Humans in Iowa

Bayer says it is disappointed by Monday’s verdict and plans to appeal. Two other juries in March and last August awarded multimillion-dollar settlements to Roundup victims, and thousands of other cases are pending against the company.

The Wall Street Journal reports the price of shares in Bayer has dropped 30% since its first courtroom defeat in August. The newspaper also says shareholders are angered the German-based company bought Monsanto last year when it sells a product suspected of causing cancer. (VOA)