Friday March 22, 2019

Poor Oral Health Can Onset Alzheimer

The findings offer hope for a new way of tackling the illness, for which there is no cure and no effective treatments.

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A patient for a regular check up of their teeth.
Picture shows a person's teeth being checked upon.

Poor oral health can play a role in onset of Alzheimer’s disease, say researchers who found evidence of the link between bacteria in a common type of gum disease and people with dementia.

The study, published in the journal Science Advances, identified Porphyromonas gingivalis — the keystone pathogen in chronic periodontitis — in the brain of Alzheimer’s disease patients.

Toxic proteases from the bacterium called gingipains were also identified in the brain of Alzheimer’s patients, and levels correlated with tau and ubiquitin pathology.

A picture of a person's teeth.
   Poor oral health can play a role in onset of Alzheimer’s disease .Pixabay

The findings offer hope for a new way of tackling the illness, for which there is no cure and no effective treatments, the BBC reported.

Tests on mice confirmed the bacteria could travel from the mouth to the brain and showed the toxic protein they secrete, called gingipain, which destroyed brain neurons.

The bacteria also increased production of amyloid beta, a component of the amyloid plaques commonly associated with Alzheimer’s.

Following this, scientists Stephen Dominy from founders of the pharmaceutical firm Cortexyme, tested drugs in mice aimed at blocking the toxic proteins and found they were able to halt degeneration in the brain.

Also Read: Weigh Gain in Women Can Be Cause Due To High Stress Jobs: Study

The same bacteria was further found in 51 out of 53 brain autopsies of Alzheimer’s disease patients.

The team has now developed a new drug they hope could form the basis of a human treatment and plan to test it in people with mild to moderate Alzheimer’s, in a clinical trial later in 2019. (IANS)

Next Story

Poor Dental Health can Lead to Obesity in Children

The study found a direct relationship between poor dental health leading to a rise in BMI (Body Mass Index) and extra body fat.

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Poor Dental Health can Lead to Obesity in Children
Poor Dental Health can Lead to Obesity in Children. Pixabay
  • Worried about your child’s obesity problems? It’s high time you curbed his love for sugary drinks and junk food. A little focus on dental care may also prevent your child gaining excess weight, says a new study.

The study found a direct relationship between poor dental health leading to a rise in BMI (Body Mass Index) and extra body fat.

“Weight can be a sensitive subject, but if you talk about eating behaviors alongside dental health, you are looking at the issue from a different angle,” said Louise Arvidsson, a doctoral student at the University of Gothenburg in Sweden.

“The question is whether a healthy diet can have the effect also in young children. There has been a lot of focus on physical activity and mental health in children, but diet is an increasingly recognized aspect.”

The researchers reviewed the eating behavior, body fat and dental health of 271 small children. The height, weight and food intake of the children were kept under observation for one day and then checked for the prevalence of cariogenic microorganisms in saliva.

The results found that the children who had a higher amount of carries bacteria also had higher BMI and worse eating habits.

The children were suggested to consume whole grain products, 400-500 grams of fruit and vegetables per day, fish two to three times a week and a low intake of sugar and saturated fat.

Arvidsson mentioned in the thesis, conducted at the University’s Sahlgrenska Academy, that with good food comes increased self-esteem, better relationships with friends and fewer emotional problems

Rather, parents who try to change the regime of their children by asking them to eat less during childhood can see serious repercussions of overweight problems in later life.(IANS)