Sunday June 16, 2019

Risks Of Intestinal Bleeding Increase With Anti-Depressants: Study

Whenever physicians discover their patients are taking any combination of these medications, they should begin assessing the risks and benefits and determine whether there are alternative treatment plans.

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Pills (representational Image), Pixabay

If you are in the habit of popping anti-depressant pills used to treat anxiety, obsessive-compulsive disorders and post-traumatic stress disorder, then you could be at a risk of intestinal bleeding which can range from mild to severe and can be life-threatening.

Gastrointestinal bleeding, also known as gastrointestinal haemorrhage, is all forms of bleeding in the gastrointestinal tract from the mouth to the rectum.

Patients taking anti-depressant medications classified as selective serotonin reuptake inhibitors (SSRIs) are 40 per cent more likely to develop severe gastrointestinal bleeding, according to a research review in the Journal of the American Osteopathic Association.

Although SSRIs are among the most frequently prescribed as they are relatively low-cost, effective and safe, they carry risks for gastrointestinal and intracranial bleeding — particularly when they also use common over-the-counter pain relievers.

Anti-depressants, prostate cancer
The antidepressant drug Prozac, also known as fluoxetine, is pictured. VOA

The most common and concerning interactions occur with nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen and naproxen, anti-coagulants like warfarin or anti-platelet medications such as aspirin and clopidogrel, the study said.

“The real risk comes from the assumption that each of these drugs is relatively safe and benign. But they all carry a risk for bleeding, and that risk increases when these medications are taken concurrently,” said lead author Wei Cheng Yuet, Assistant Professor at the University of North Texas Health Science Centre.

According to Yuet, a significant portion of SSRI prescriptions are written by primary care physicians.

The risk of bleeding is well established but not well known among patients, she said, while encouraging physicians to take a full inventory of the medications their patients take, including over-the-counter NSAIDs.

Anti-depressants
The risk of bleeding is well established but not well known among patients.

“Whenever physicians discover their patients are taking any combination of these medications, they should begin assessing the risks and benefits and determine whether there are alternative treatment plans,” Yuet said.

“For example, physicians should periodically assess antidepressant use even when patients are stable on therapy.”

Also Read: New Expanding Pills To Track Ulcers and Stomach Cancer

Yuet also recommends physicians monitor their patients closely for symptoms of gastrointestinal bleeding during the first 30 days of SSRI therapy, especially if patients are taking concurrent medications that may increase bleeding risk. (IANS)

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Health Alert! Be Cautious While Taking Pills With Inactive Ingredients, Can Lead To Adverse Reactions

"While we call these ingredients 'inactive', in many cases they are not. While the doses may be low, we don't know what the threshold is for individuals to react in the majority of instances," the researchers noted. 

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medicines
For certain drugs, such as progesterone, there are few alternatives that do not contain this inactive ingredient. VOA

Be cautious while taking medicines as a new study suggests that some ingredients added to pills to improve their shelf life may cause allergy or lead to adverse reactions.

The study found that more than 90 per cent of all oral medications tested contained at least one ingredient including lactose, peanut oil, gluten and chemical dyes that can cause gastrointestinal issues and difficulty in breathing in sensitive individuals.

These components are added to improve the taste, shelf life, absorption and other characteristics of a pill, said researchers from the Massachusetts Institute of Technology (MIT) in the US.

Pills
“While we call these ingredients ‘inactive’, in many cases they are not. While the doses may be low, we don’t know what the threshold is for individuals to react in the majority of instances,” the researchers noted. 
VOA

“There are hundreds of different versions of pills or capsules that deliver the same medication using a different combination of inactive ingredients,” said Daniel Reker from the varsity.

For the study, published in the journal Science Translational Medicine, the team analysed data on inactive ingredients in over 42,000 oral medications that contained more than 350,000 inactive ingredients.

The findings showed a total of 38 inactive ingredients that cause allergic symptoms after oral exposure. Approximately 45 per cent of medications contained lactose, nearly 33 per cent contained a food dye, and 0.08 per cent contained peanut oil.

Pills
“There are hundreds of different versions of pills or capsules that deliver the same medication using a different combination of inactive ingredients,” VOA

For certain drugs, such as progesterone, there are few alternatives that do not contain this inactive ingredient.

Also Read: Know When Older Adults Feel Younger Than Their Age

“While we call these ingredients ‘inactive’, in many cases they are not. While the doses may be low, we don’t know what the threshold is for individuals to react in the majority of instances,” the researchers noted.

Precision care and the role for regulation and legislation are essential when it comes to labelling medications that contain an ingredient that may cause an adverse reaction, the team suggested. (IANS)