Monday April 22, 2019

Scientists Claim, Absence Of KDM5 Protein in Flies Causes Autism

The study, published in the journal Cell Host and Microbe, showed without the function of KDM5, the flies' intestinal mucosal barriers were damaged and their intestinal flora was imbalanced. 

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"Many people with autism also have a serious intestinal illness, like diarrhea and irritable-bowel syndrome. It is consistent with our findings," Liu said. Pixabay

 Chinese scientists have discovered that absence of a certain protein in flies causes intestinal flora imbalance and makes them show symptoms similar to autism in humans.

The team, led by Professor Liu Xingyin of Nanjing Medical University in China, said the discovery could lead to a new theoretical path of treating autism based on digestion and immune activities, the Xinhua reported.

Xingyin said the KDM5-deficient drosophila melanogaster, or vinegar flies, kept their distance from one another, were slow to respond and had reduced direct contact with other flies.

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Former studies about autism usually focused on genetics,” he said. “We are looking forward to opening a new road for human autism therapy from the perspective of human digestion and the immune system,” Liu said. Pixabay

“All of these phenomena are similar to the communication disorders of people with autism,” Liu said.

The study, published in the journal Cell Host and Microbe, showed without the function of KDM5, the flies’ intestinal mucosal barriers were damaged and their intestinal flora was imbalanced.

autism
The team, led by Professor Liu Xingyin of Nanjing Medical University in China, said the discovery could lead to a new theoretical path of treating autism based on digestion and immune activities, the Xinhua reported. Pixabay

“Many people with autism also have a serious intestinal illness, like diarrhea and irritable-bowel syndrome. It is consistent with our findings,” Liu said.

Also Read:High Level Of Insulin in Infants May Rise Chances Of Brain Damage
Further research also discovered that using antibiotics or feeding lactobacillus plantarum could improve social behaviour as well as the lifespan of some KDM5-deficient flies.

“Former studies about autism usually focused on genetics,” he said. “We are looking forward to opening a new road for human autism therapy from the perspective of human digestion and the immune system,” Liu said. (IANS)

 

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Know Which Gene in Your Body Could Help Brain Heal Itself After A Stroke

It is unlikely that gene therapy delivered by viruses will become the go-to treatment for strokes.

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Jung further added that not all inflammation in the brain is bad as it plays a role in fighting infection and helps clear away dead tissue. However, inflammation for a long duration could lead to the death of neurons. Pixabay

Researchers have found that a gene could help the brain heal itself after a stroke or any other head-related injuries.

The study, published in Cell Reports, suggested that a dose of the TRIM9 gene could reduce brain swelling after stroke, prevent damage following a blow to the head (concussion) or encephalitis, which is the inflammation of the brain.

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The is because TRIM9 is abundant in the youthful brain but grows scarce with age. Pixabay

In addition, in a lab model, the researchers from the University of Southern California found that older brains with low TRIM9 levels — or engineered brains missing the TRIM9 gene entirely — were prone to extensive swelling following a stroke.

The is because TRIM9 is abundant in the youthful brain but grows scarce with age.

On the other hand, when the team used a harmless virus to carry a dose of the gene directly into TRIM9-deficient brains, the swelling decreased dramatically and recovery improved, the findings further revealed.

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The study, published in Cell Reports, suggested that a dose of the TRIM9 gene could reduce brain swelling after stroke, prevent damage following a blow to the head (concussion) or encephalitis, which is the inflammation of the brain. Pixabay

It is unlikely that gene therapy delivered by viruses will become the go-to treatment for strokes, head injuries or encephalitis as the best shot at treating stroke is within the first 30 minutes to one hour, said lead author Jae Jung at the varsity.

Also Read: This Slum School in Gurugram Has Walls That Speak Through its Wall Paintings

Jung further added that not all inflammation in the brain is bad as it plays a role in fighting infection and helps clear away dead tissue. However, inflammation for a long duration could lead to the death of neurons. (IANS)