Sunday December 8, 2019

Scientists Claim, Absence Of KDM5 Protein in Flies Causes Autism

The study, published in the journal Cell Host and Microbe, showed without the function of KDM5, the flies' intestinal mucosal barriers were damaged and their intestinal flora was imbalanced. 

0
//
autism
"Many people with autism also have a serious intestinal illness, like diarrhea and irritable-bowel syndrome. It is consistent with our findings," Liu said. Pixabay

 Chinese scientists have discovered that absence of a certain protein in flies causes intestinal flora imbalance and makes them show symptoms similar to autism in humans.

The team, led by Professor Liu Xingyin of Nanjing Medical University in China, said the discovery could lead to a new theoretical path of treating autism based on digestion and immune activities, the Xinhua reported.

Xingyin said the KDM5-deficient drosophila melanogaster, or vinegar flies, kept their distance from one another, were slow to respond and had reduced direct contact with other flies.

autism
Former studies about autism usually focused on genetics,” he said. “We are looking forward to opening a new road for human autism therapy from the perspective of human digestion and the immune system,” Liu said. Pixabay

“All of these phenomena are similar to the communication disorders of people with autism,” Liu said.

The study, published in the journal Cell Host and Microbe, showed without the function of KDM5, the flies’ intestinal mucosal barriers were damaged and their intestinal flora was imbalanced.

autism
The team, led by Professor Liu Xingyin of Nanjing Medical University in China, said the discovery could lead to a new theoretical path of treating autism based on digestion and immune activities, the Xinhua reported. Pixabay

“Many people with autism also have a serious intestinal illness, like diarrhea and irritable-bowel syndrome. It is consistent with our findings,” Liu said.

Also Read:High Level Of Insulin in Infants May Rise Chances Of Brain Damage
Further research also discovered that using antibiotics or feeding lactobacillus plantarum could improve social behaviour as well as the lifespan of some KDM5-deficient flies.

“Former studies about autism usually focused on genetics,” he said. “We are looking forward to opening a new road for human autism therapy from the perspective of human digestion and the immune system,” Liu said. (IANS)

 

Next Story

Deep Sleep Can Reduce Higher Anxiety Levels

A Study strongly suggests that insufficient sleep amplifies levels of anxiety and, conversely, that deep sleep helps reduce such stress

0
Deep
Deep Sleep had restored the brain's prefrontal mechanism that regulates our emotions, lowering emotional and physiological reactivity and preventing the escalation of anxiety. Pixabay

Researchers have found that the type of Sleep most apt to calm and reset the anxious brain is deep sleep, also known as non-rapid eye movement (NREM) slow-wave sleep, a state in which neural oscillations become highly synchronised, and heart rates and blood pressure drops.

A sleepless night can trigger up to a 30 per cent rise in anxiety levels, researchers from the University of California said.

“We have identified a new function of deep sleep, one that decreases anxiety overnight by reorganising connections in the brain,” said study senior author Professor Matthew Walker.

“Deep sleep seems to be a natural anxiolytic (anxiety inhibitor), so long as we get it each and every night,” Walker added.

“Our study strongly suggests that insufficient sleep amplifies levels of anxiety and, conversely, that deep sleep helps reduce such stress,” said study lead author Eti Ben Simon.

In a series of experiments using functional MRI and polysomnography, among other measures, researchers scanned the brains of 18 young adults as they viewed emotionally stirring video clips after a full night of sleep, and again after a sleepless night.

Anxiety levels were measured following each session via a questionnaire known as the state-trait anxiety inventory.

After a night of no sleep, brain scans showed a shutdown of the medial prefrontal cortex, which normally helps keep our anxiety in check, while the brain’s deeper emotional centres were overactive.

Deep
Researchers have found that the type of Sleep most apt to calm and reset the anxious brain is Deep sleep, also known as non-rapid eye movement (NREM) slow-wave sleep, a state in which neural oscillations become highly synchronised, and heart rates and blood pressure drops. Pixabay

After a full night of sleep, during which participants’ brain waves were measured via electrodes placed on their heads, the results showed their anxiety levels declined significantly, especially for those who experienced more slow-wave NREM sleep.

“Deep sleep had restored the brain’s prefrontal mechanism that regulates our emotions, lowering emotional and physiological reactivity and preventing the escalation of anxiety,” Simon said.

ALSO READ: Glaciers in Alaska Melting due to Climate Change

Beyond gauging the sleep-anxiety connection in the 18 original study participants, the researchers replicated the results in a study of another 30 participants.

Across all the participants, the results again showed that those who got more nighttime deep sleep experienced the lowest levels of anxiety the next day.  (IANS)