Thursday October 18, 2018

Study: Diabetes Treatment Gets Boost From ‘Surgery in a Pill’

Novel 'surgery in a pill' to reverse diabetes

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Study: Diabetes Treatment Gets Boost From 'Surgery in a Pill'
Study: Diabetes Treatment Gets Boost From 'Surgery in a Pill'. (IANS)
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Researchers have developed “surgery in a pill” that can reduce post-meal blood sugar spikes and help reverse diabetes.

When the pill was administered in rats, it delivered a substance that could temporarily coat the intestine, forming a thin barrier that alters nutrient contact and lowers blood glucose response after a meal, the researchers said.

“We envision a pill that a patient can take before a meal that transiently coats the gut to replicate the effects of surgery,” said Jeff Karp, a bioengineer at the Brigham and Women’s Hospital (BWH) in Massachusetts, US.

After a meal, blood sugar levels rise and can stay elevated over time.

However, one hour after the pill was administered to the rats, the response to glucose was lowered by 47 per cent.

“What we’ve developed here is essentially, ‘surgery in a pill’,” added Yuhan Lee, a materials scientist in the BWH.

This response was temporary, and after three hours, the effect essentially disappeared, the study showed.

Representational image.
Representational image. Pixabay

For the study, published in the journal Nature Materials, the team selected a substance known as sucralfate — an FDA-approved drug that is used in the treatment of gastrointestinal ulcers — to adhere to the small intestine and then dissolve within a matter of hours.

Further, the team engineered the substance into a novel material that can coat the lining of the intestine without requiring activation by gastric acid.

The engineered compound, referred to as LuCI (Luminal Coating of the Intestine), can be made into a dry powdered form that can be encapsulated as a pill.

Also Read: Thyroid Dysfunction May Lead to Diabetes During Pregnancy

“We’ve used a bioengineering approach to formulate a pill that has good adhesion properties and can attach nicely to the gut in a preclinical model. And after a couple of hours, its effects dissipate,” Lee said.

The team is now testing the effect of short-and long-term use of LuCI in diabetic and obese rodent models. (IANS)

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Avoid Diabetes With Yoga, Weight Lifting

They studied the effects of weekly time spent on resistance exercise, lower intensity muscular conditioning exercises and aerobic moderate and vigorous physical activity

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Yoga
Avoid Diabetes by practicing Yoga. Pixabay

If you wish to avoid diabetes, better start exercising for just half-an-hour a day, a Harvard University research has found while advising yoga and weight lifting.

According to the research, the chance of developing Type 2 diabetes was cut by between 30 and 40 per cent with just three-and-a-half hours of exercise a week, Daily Mail reported Wednesday.

It was also found that just an hour’s workout every week could cut the risk by 13 percent.

The study, which followed 100,000 women, also showed muscle-strengthening exercises such as yoga and weight lifting fend off the condition.

Scientists showed that those doing at least 150 minutes of aerobic activity a week – and at least an hour of muscle-strengthening – had the best results.

Weight Lifting
Weight Lifting. Pixabay

Published by the journal PLOS Medicine, the study was carried out by scientists from Harvard School of Public Health and the University of Southern Denmark.

Researchers studied 99,316 middle-aged and older women, who did not have diabetes at the beginning of the study, for eight years. During the period, 3,491 women developed Type 2 diabetes.

They studied the effects of weekly time spent on resistance exercise, lower intensity muscular conditioning exercises and aerobic moderate and vigorous physical activity.

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“Our study suggests that engagement in muscle-strengthening and conditioning activities (resistance exercise, yoga, stretching, toning) is associated with a lower risk of (Type 2 diabetes),” the researchers said.

“Despite limitations to which this research can be applied to women in general, it underlines the message that leading an active healthy lifestyle can help to reduce the risk of Type 2 diabetes,” said Richard Elliott, research communications officer at Diabetes, UK. (IANS)