Wednesday March 20, 2019

Researchers Discover Treatment for Obesity, Fatty Liver Disease

Goldblum predicts that in a few years we will hopefully be seeing several of these molecules in the pipeline for clinical studies on humans

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Obesity
An overweight woman sits on a chair in Times Square in New York, May 8, 2012. VOA

Israeli researchers have discovered 27 new molecules, which may lead to a potential treatment for fatty liver disease, obesity and to heal wounds.

The findings, led by Professor Amiram Goldblum at the Hebrew University of Jerusalem, were made possible by a new algorithm, which chose the 27 molecules with the strongest therapeutic potential from a database of 1.56 million molecules.

These molecules, which are undergoing pharmaceutical evaluations to treat obesity and the incurable fatty liver disease, all activate a special protein called PPAR-delta (peroxisome proliferator-activated receptor delta).

PPAR-delta activation has the potential to increase physical endurance and trim waistlines by getting muscle cells to burn more fat, according to the study published in the Scientific Reports journal.

“With such a large group of highly active molecules, there is a high probability to find treatments for several common diseases. However, we should wait till all the experiments are done before we get our hopes up too high,” said Goldblum.

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Soon treatment for obesity, fatty liver disease . Pixabay

Future evaluations will hopefully include testing treatments for improved wound healing, and to prevent kidney toxicity in diabetics, the researchers said.

There is much pharmaceutical interest in Goldblum’s new molecules.

Integra Holdings, Hebrew University’s biotech company, determined that 21 of the 27 have the potential to reach pharmaceutical success, especially as a possible cure for fatty liver disease.

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In addition, Israel’s Heller Institute of Medical Research is currently testin g PPAR-delta’s physical endurance properties on mice.

Goldblum predicts that in a few years we will hopefully be seeing several of these molecules in the pipeline for clinical studies on humans. (IANS)

Next Story

Research Reveals: It’s Your Friend’s Company That Can Turn You Obese

Social contagion in obesity means if more people around you are obese, then that may increase your own chances of becoming obese.

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Unhealthy food promotes obesity. pixabay

Besides genes and an unhealthy diet, your friends can also play a role in making you overweight, says a study, which found that obesity can spread through communities like a ‘social contagion’.

The study showed social circles can influence a person to become obese, suggesting the risk of becoming overweight increases if one moves to an area with a high rate of obesity, the Daily Mail reported.

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On the other hand, the risk of the parent becoming obese or overweight went up five per cent for increase in every one per cent of obesity in the area. Pixabay

“Social contagion in obesity means if more people around you are obese, then that may increase your own chances of becoming obese. Subconsciously, you are affected by what people around you are doing,” said Ashlesha Datar at the University of Southern California.

“If you move to a community where a sedentary lifestyle is the norm, you join that. There is this social influence,” Datar said.

For the study, the team included 1,314 parents and 1,111 children of US Army personnel at 38 bases.

The chances of becoming overweight or obese for a teenager increased four-six per cent for rise in every one per cent in the obesity.

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If you move to a community where a sedentary lifestyle is the norm, you join that. There is this social influence,” Datar said. Pixabay

On the other hand, the risk of the parent becoming obese or overweight went up five per cent for increase in every one per cent of obesity in the area.

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The longer the families lived there, the more likely they put on weight, the report said.

Obesity can be caused by many variables, and previous research has shown living in certain communities carries a higher risk of obesity than living in other communities. (IANS)