Vitamin C Treatment During Pregnancy Can Cut Babies’ Risk of Heart Diseases
It turns out that vitamin C is a comparatively weak antioxidant, and while the Cambridge study provides a proof-of-principle, future work will focus on identifying alternative antioxidant therapies that could prove more effective in human clinical practice
Maternal treatment with vitamin C antioxidant during a complicated pregnancy could protect the baby from developing hypertension and heart disease in adulthood, suggests a study.
Heart disease is the greatest killer in the world today, and it is widely accepted that our genes interact with traditional lifestyle risk factors such as smoking, obesity and/or a sedentary life to promote an increased risk of cardiovascular disease.
However, a new study on sheep by a team from Cambridge University, finds that babies born from pregnancies complicated by chronic hypoxia have increased indicators of cardiovascular disease such as high blood pressure and stiffer blood vessels.
Chronic hypoxia or lower-than-normal oxygen levels in the developing baby within the womb is one of the most common outcomes of complicated pregnancy in humans. It occurs as a result of problems within the placenta, as can occur in preeclampsia, gestational diabetes or maternal smoking.
“Our discoveries emphasise that when considering strategies to reduce the overall burden of heart disease, much greater attention to prevention rather than treatment is required,” said lead researcher Dino Giussani, Professor from the varsity.
“Treatment should start as early as possible during the developmental trajectory, rather than waiting until adulthood when the disease process has become irreversible,” Giussani added.
The study, published in the journal PLOS Biology, draws attention to a new way of thinking about heart disease with a much longer term perspective, focusing on prevention rather than treatment.
The team used pregnant sheep to show that maternal treatment with the antioxidant vitamin C during a complicated pregnancy could protect the adult offspring from developing hypertension and heart disease.
The study not only provides evidence that a prenatal influence on later heart disease in the offspring is indeed possible, but also shows the potential to protect against it by “bringing preventative medicine back into the womb”, said Kirsty Brain from the varsity.
It turns out that vitamin C is a comparatively weak antioxidant, and while the Cambridge study provides a proof-of-principle, future work will focus on identifying alternative antioxidant therapies that could prove more effective in human clinical practice, the research said. (IANS)
Human health is paying the price of the world’s failure to curb global warming, the World Health Organization warned on Tuesday, urging governments at U.N. climate talks to cut climate-changing emissions faster and provide funds to address growing threats.
Those range from lung and heart problems caused by toxic air to deaths in storms and wildfires, and the expansion of dengue, malaria, cholera and other diseases spread by mosquitoes and contaminated water.
“The cost of not taking enough action at the climate summit … is paid by my lungs and your lungs,” said Maria Neira, director of the department of environment, climate change and health at the World Health Organization (WHO), a U.N. agency.
The causes of climate change and air pollution overlap, she added, calling for societies to “decarbonize,” including by ditching coal as a source of power and heat, and ending subsidies for the extraction and use of fossil fuels.
According to the WHO, the burning of oil, gas and coal is responsible for two-thirds of the outdoor air pollution that causes about 4 million premature deaths each year.
More intense and longer heat waves are another growing health problem in many parts of the world.
A study published in the journal Nature on Monday found extreme heat in the United States from 1969-1988 caused an increase in deliveries of babies on the day it hit and the day after, with those births happening up to two weeks before they were due.
Such early births can potentially harm children’s later development, researchers said.
At the Madrid climate talks Tuesday, activists and aid agencies cited a rise in hospital emissions linked to smoke from Australia’s recent bushfires.
In southern African countries hit by Cyclone Idai this year, they said, people are struggling to feed their families after fields and homes were destroyed.
To deal with the rising human and financial health costs of climate change, health services and related institutions need a boost in funding — currently sorely lacking, the WHO said.
On Tuesday, it released a report highlighting how countries are increasingly prioritizing dealing with climate change threats to health.
Half of about 100 nations surveyed said they had developed a national strategy or plan to tackle the risks.
Paying for improvements
But only about 38% had finances in place to even partially implement their plans, and fewer than 10% had the money to put them fully into practice, the report showed.
Diarmid Campbell-Lendrum, WHO’s coordinator for climate change and health, said all countries surveyed — from Europe to the Americas, Africa and Asia — are struggling to finance measures such as protecting hospitals from weather disasters and ramping up disease surveillance.
In richer countries, the difficulty lies in securing allocations from national budgets due to competing priorities.
Poorer nations, on the other hand, need international climate finance to help them cope, but are struggling to access it because of a lack of information, capacity and connections.
As a result, less than half a percent of international climate finance has gone to projects to head off climate risks to health, Campbell-Lendrum said.
“These countries are exposed, they are vulnerable and they are unsupported,” he added.
The WHO plans to help developing countries put together projects to bolster their health systems that can secure backing from international climate funds, he added.
One of the biggest potential sources of finance, the Green Climate Fund, has identified health and well being as a priority area but has yet to approve any projects with that focus, Campbell-Lendrum noted.
Things that could be financed might include “smart hospitals” — now being tested in the Caribbean — built to withstand strong winds and floods while also harvesting rainwater and running on solar power.
Off-grid renewable energy projects also can cut emissions from health facilities and make them more resilient in disasters when electricity networks go down, Campbell-Lendrum said.
He noted that the mental health impacts of climate change had “shot up the agenda.”