New York, March 11, 2017: The deadly Zika virus, which is already known to cause birth defects and a neurological condition that can lead to paralysis, may have serious adverse effects on the heart, says a study.
In a study of a small group of adult patients with Zika and no previous history of cardiovascular disease, all but one developed a heart rhythm problem and two-thirds had evidence of heart failure, the researchers said.
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“We know that other mosquito-borne diseases, such as dengue fever and chikungunya virus, can affect the heart, so we thought we might see the same with Zika. But we were surprised by the severity, even in this small number of patients,” said the study’s lead author Karina Gonzalez Carta, cardiologist and research fellow at Mayo Clinic in the US.
The findings are scheduled to be presented at the American College of Cardiology’s 66th Annual Scientific Session on March 18 in d in Washington, DC.
The nine patients (six were female, and mean age was 47) were seen at the Institute of Tropical Medicine in Caracas, Venezuela, within two weeks of having Zika-type symptoms.
They reported symptoms of heart problems, most commonly palpitations followed by shortness of breath and fatigue.
Only one patient had any previous cardiovascular problems (high blood pressure), and tests confirmed that all of the patients had active Zika infection.
Patients underwent an initial electrocardiogram (EKG), a test that shows the electrical activity of the heart, and in eight of the patients, the EKG suggested heartbeat rate or rhythm concerns.
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These findings prompted further examination which showed serious arrhythmias (improper beating of the heart) in eight patients and heart failure in six cases.
The patients have been followed since July 2016, and none of their cardiac issues have resolved, but symptoms have improved following treatment for heart failure or atrial fibrillation, Carta said.
It is known that Zika can cause microcephaly, a severe birth defect in babies born to women infected with the virus, and Guillain-Barré syndrome, a neurological condition that can lead to muscle weakness and, in severe cases, paralysis.
“Following this research, we want patients who are suffering from Zika symptoms also to be aware of the cardiac symptoms because they might not connect the two,” Carta said. (IANS)
Washington, Sep 26: An anti-dengue antibody-based drug could potentially protect a mother and her foetus from the deadly Zika virus as well, suggests new research.
In experiments with mice, the researchers found that an antibody that protects against dengue virus is also effective against Zika.
“We found that this antibody not only neutralises the dengue virus but, in mice, protects both adults and foetuses from Zika disease,” said Michael Diamond, Professor at Washington University School of Medicine in St. Louis, and senior author of the study published in the journal Nature Immunology.
Antibodies remain in the bloodstream for weeks, so one or a few doses of an antibody-based drug given over the course of a woman’s pregnancy potentially could protect her foetus from Zika, with the added benefit of protecting her from both Zika and dengue disease, the researchers said.
Dengue causes high fever, severe headaches, and joint and muscle pain in children and adults but does not directly harm foetuses.
Since dengue and Zika are related viruses, the researchers reasoned that an antibody that prevents dengue disease may do the same for Zika.
In collaboration with Gavin Screaton of Imperial College London, who had generated a panel of human anti-dengue antibodies years before, the scientists infected nonpregnant adult mice with Zika virus and then administered one of the anti-dengue antibodies one, three or five days after infection.
For comparison, another group of mice was infected with Zika virus and then given a placebo.
Within three weeks of infection, more than 80 per cent of the untreated mice had died, whereas all of the mice that received the anti-dengue antibody within three days of infection were still alive, and 40 per cent of those that received the antibody five days after infection survived.
To find out whether the antibody also could protect foetuses from infection, the researchers infected female mice on the sixth day of their pregnancies with Zika virus and then administered a dose of antibody or a placebo one or three days later.
On the 13th day of gestation, the amount of Zika’s genetic material were significantly lower in the placentas and in the foetal heads from the pregnant mice that were treated one day after infection, compared with mice that received the placebo.
However, administering the antibody three days after infection was less effective, the findings showed.
These findings suggest that for the antibody to effectively protect foetuses from Zika infection, it must be administered soon after infection.
Such a goal may be unrealistic clinically because women rarely know when they get infected.
However, giving women the antibody as soon as they know they are pregnant could provide them with a ready-made defence against the virus should they encounter it.
“We mutated the antibody so that it could not cause antibody enhancement of dengue infection, and it was still protective,” said Diamond.
“So now we have a version of the antibody that would be therapeutic against both viruses and safe for use in a dengue-endemic area because it is unable to worsen disease,” Diamond added.(IANS)
When a drop of the patient's blood is applied on the paper mounted on the nanorods, the immunoglobulins in the blood will react with the protein if the patient has come into contact with the virus and demonstrate a colour change
Scientists have developed a nanotechnology based test that can quickly detect the presence of the Zika virus in the blood
The new test relies on a protein made by the Zika virus
The test is very quick as the results would be declared before the patient even leaves the clinic
New Delhi, August 13, 2017: Scientists, including one of Indian-origin, have developed a nanotechnology-based test that can quickly detect the presence of the Zika virus in the blood, an advance that may also be applicable to other emerging infectious diseases.
Currently, testing for Zika requires that a blood sample be refrigerated and shipped to a medical centre or laboratory, delaying diagnosis and possible treatment for Zika virus.
The new test, however, relies on a protein made by the Zika virus that causes an immune response in infected individuals, which is then attached to tiny gold nanorods mounted on a piece of paper.
The paper then is completely covered with tiny, protective nanocrystals. The nanocrystals allow the diagnostic nanorods to be shipped and stored without refrigeration prior to use, the researchers said.
“If an assay requires electricity and refrigeration, it defeats the purpose of developing something to use in a resource-limited setting, especially in tropical areas of the world,” said Srikanth Singamaneni, Associate Professor at the Washington University in St. Louis.
“We wanted to make the test immune from variations in temperature and humidity,” Singamaneni added.
When a drop of the patient’s blood is applied on the paper mounted on the nanorods, the immunoglobulins in the blood will react with the protein if the patient has come into contact with the virus and demonstrate a colour change.
“The immunoglobulins persist in the blood for a few months, and when they come into contact with the gold nanorods, the nanorods undergo a slight colour change that can be detected with a hand-held spectrophotometer,” explained Jeremiah J. Morrissey, Professor at the varsity.
“With this test, results will be clear before the patient leaves the clinic, allowing immediate counselling and access to treatment,” he added in the paper detailed in the journal Advanced Biosystems.
As other infectious diseases emerge around the world, similar strategies potentially could be used to develop tests to detect the presence of viruses that may become problematic, the researchers said. (IANS)
Depending on the location, the proliferation of IS has drawn varied resistance from the Afghan military, U.S. air support and ground troops, local militias, Taliban forces and other militant groups
Afghan army planes on Wednesday night accidentally air dropped vital supplies of food and water to IS militants in the Darzab district of northern Jouzjan province instead of to their own besieged troops
In the Tora Bora area, where IS has made a strong stand in recent days, local villagers and militias joined with Taliban to rout IS
June 25, 2017: The Islamic State group is rapidly expanding in parts of Afghanistan, advancing militarily into areas where it once had a weak presence and strengthening its forces in core regions, according to Afghan and U.S. officials.
Depending on the location, the proliferation of IS has drawn varied resistance from the Afghan military, U.S. air support and ground troops, local militias, Taliban forces and other militant groups.
Attacking IS has become such a priority in the country, that disparate forces sometimes join together in the ad-hoc fight, with Afghan and U.S. forces finding themselves inadvertently supporting the enemy Taliban in battling IS.
Confusion leads to mistakes
All too often, officials say, mistakes are made due to confusion on the ground.
Afghan army planes on Wednesday night accidentally air dropped vital supplies of food and water to IS militants in the Darzab district of northern Jouzjan province instead of to their own besieged troops, provincial police chief, Rahmatullah Turkistani told VOA. The supplies were meant to help Afghan forces that are countering twin attacks by IS and Taliban militants but were used instead by IS.
“It’s not getting better in Afghanistan in terms of IS,” U.S. Chief Pentagon Spokeswoman Dana White told VOA this week. “We have a problem, and we have to defeat them and we have to be focused on that problem.”
Reinforcements for the IS cause reportedly are streaming into isolated areas of the country from far and wide. There are reports of fighters from varied nationalities joining the ranks, including militants from Pakistan, India, Iran, Iraq, Syria, Russia and Central Asian neighbors.
Still, the Islamic State-Khorasan (ISK) as IS is known in Afghanistan remains a fragmented group composed of differing regional forces with different agendas in different parts of the country.
“IS-K is still conducting low-level recruiting and distribution of propaganda in various provinces across Afghanistan, but it does not have the ability or authority to conduct multiple operations across the country,” a recent Pentagon report said. But where it operates, IS is inflicting chaos and casualties and causing confusing scenarios for disparate opponents.
In the Tora Bora area, where IS has made a strong stand in recent days, local villagers and militias joined with Taliban to rout IS. IS regained ground after a few days, leading to U.S. military air attacks on IS positions in conjunction with Afghan intelligence instructions and army operations.
IS fighters reportedly have fled from mountain caves of Tora Bora, where al-Qaida’s leader Osama bin Laden hid from U.S. attack in 2001.
IS fighters were also reportedly advancing in neighboring Khogyani district, displacing hundreds of families, according to district officials. It is one of several areas in Nangarhar province, near the Pakistani border, where IS has been active for over two years.
Fierce clashes in the Chaparhar district of Nangarhar last month left 21 Taliban fighters and seven IS militants dead, according to a provincial spokesman. At least three civilians who were caught in the crossfire were killed and five others wounded.
“IS has overpowered Taliban in some parts of Nangarhar because the Taliban dispatched its elite commando force called Sara Qeta (Red Brigade) to other parts of the country, including some northern provinces to contain the growing influence of IS there,” Wahid Muzhda, a Taliban expert in Kabul, told VOA.
IS has also expanded in neighboring Kunar province, where, according to provincial police chief, it has a presence in at least eight districts and runs a training base, where foreign members of IS, train new recruits.
Hundreds of miles from Nangarhar, IS is attempting to establish a persistent presence in several northern provinces where it has found a fertile ground for attracting militants and recruiting unemployed youths, mostly between the age of 13 and 20.
IS has been able to draw its members from the Pakistani Taliban fighters, former Afghan Taliban, and other militants who “believe that associating with or pledging allegiance” to IS will further their interests, according to the Pentagon report.
Hundreds of militants have joined IS ranks in northern Jouzjan and Sar-e-Pul province where local militant commanders lead IS-affiliate groups in several districts.
Qari Hekmat, an ethnic Uzbek and former Taliban militant who joined IS a year ago, claims to have up to 500 members, including around 50 Uzbek nationals who are affiliated with the Islamic Movement of Uzbekistan (IMU) — previously associated with al-Qaida and Taliban in Afghanistan.
IS and Taliban are reportedly fighting over the control of Darzab district in Jouzjan which they stormed this week from two different directions and besieged scores of government forces. The Taliban has reportedly captured the center of the district while IS militants control the city outskirts.
Afghanistan faces a continuing threat from as many as 20 insurgent and terrorist networks present or operating in the Afghanistan-Pakistan region, including IS, the Pentagon said.
“In areas where the government has limited influence and control, IS attempts to emerge and expand there,” Ateequllah Amarkhail, an analysts and former Army general in Kabul told VOA.
IS has also claimed responsibility for several recent attacks in urban areas, however, with a hit-and-hide strategy that is proving effective. And it is engaging too in more skirmishes with U.S. forces that initially were sent to the country to help Afghan forces halt the spread of Taliban.
Three American service members based in eastern Afghanistan were killed in April during operations targeting IS militants, according to the Pentagon.
“ISIS-K remains a threat to Afghan and regional security, a threat to U.S. and coalition forces, and it retains the ability to conduct high-profile attacks in urban centers,” the Pentagon said. (VOA)