Tuesday September 17, 2019

Hearing Loss Can Effect Your Memory

According to a 2016 study published in the Indian Journal of Otolaryngology and Head and Neck Surgery, 63 million people (6.3 per cent) suffer from significant auditory loss in India.

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Structure of brain can help find the causes behind epilepsy.
Structure of brain can help find the causes behind epilepsy.

Hearing loss can lead to impaired memory and higher risk of dementia and ensuing Alzheimer’s disease in older people, health experts say.

Deafness, according to the World Health Organisation (WHO), refers to the complete loss of hearing ability in one or both ears, while “hearing impairment” refers to both complete and partial loss of hearing ability.

Nearly 360 million people, nearly one-tenth of them children, suffer from hearing loss worldwide.

“Yes, hearing loss can lead to cognitive decline. Our two senses — vision and hearing — contribute to our cognitive development. When we are not able to hear well, most of the information that is delivered to us that way is not received properly. This way, less hearing slowly contributes to cognitive decline,” Suresh Singh Naruka, Senior Consultant – ENT at Indraprastha Apollo Hospitals here, told IANS.

Concussion without loss of consciousness led to 2.36 times the risk for dementia, showed the findings published in the journal JAMA Neurology.
Head blows can cause dementia, Pixabay

“It is important to understand that brain development and cognition development is a slow process. Intelligence is not a static thing; it is a dynamic and continuous process. It may not be visible in a day or two, but over a period of time one can witness the decline in cognitive behaviour,” Naruka added.

A study led by researchers at Brigham and Women’s Hospital in the US suggests that hearing loss is associated with new onset of subjective cognitive concerns which may be indicative of early stage changes in cognition.

The study, published in the Alzheimer’s and Dementia journal, examined 10,107 men aged 62 years.

The team found that compared with men with no hearing loss, the relative risk of cognitive decline was 30 per cent higher among men with mild hearing loss, 42 per cent higher among men with moderate hearing loss and 54 per cent higher among men with severe hearing loss but who did not use hearing aids.

The findings may help identify individuals at greater risk of cognitive decline.

It may help identify individuals at greater risk of cognitive decline and could provide insights for earlier intervention and prevention, the researchers said.

Moreover, “while hearing loss can lead to impaired memory and higher risk of dementia in older people, in children it hampers with development of speech and brain development”, Virender Singh, Consultant – ENT, Fortis Hospital, Shalimar Bagh, told IANS.

According to a 2016 study published in the Indian Journal of Otolaryngology and Head and Neck Surgery, 63 million people (6.3 per cent) suffer from significant auditory loss in India.

Four in every 1,000 children suffer from severe to profound hearing loss in India. With over 100,000 babies that are born with hearing deficiency every year, the estimated prevalence of adult-onset deafness in India was found to be 7.6 per cent and childhood-onset deafness to be 2 per cent.

“Hearing loss is a much neglected phenomenon in our country. Congenital deafness or any neonatal disease such as prolonged jaundice, meningitis or prolonged labour leading to delayed oxygenation can cause mild to profound hearing loss in neonate,” Singh said.

Depression related to brain mechanism.
Depression related to brain mechanism. IANS

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Hearing loss in children can hamper the development of speech and the brain. This can lead to shutting the child from worldly sounds, resulting in a disconnect from the social world.

“Early corrective measures in the form of hearing aid, cochlear implant, medications and corrective surgery should be taken as soon as possible to prevent any complications that arise from hearing loss,” Singh suggested. (IANS)

Next Story

Researchers Discover New Drug Which may Protect Against Memory Loss, Nerve Damage and Other Symptoms of Alzheimer’s Disease

BPN14770, under development by Tetra Therapeutics, could help activate these mechanisms that support nerve health and prevent dementia

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Drug, Memory Loss, Nerve Damage
Preclinical research published in the Journal of Pharmacology and Experimental Therapeutics found that the drug -- called BPN14770 -- deters the effects of amyloid beta, a hallmark protein of Alzheimer's that is toxic to nerve cells. Pixabay

Researchers have discovered a new drug which may protect against memory loss, nerve damage and other symptoms of Alzheimer’s disease.

Preclinical research published in the Journal of Pharmacology and Experimental Therapeutics found that the drug — called BPN14770 — deters the effects of amyloid beta, a hallmark protein of Alzheimer’s that is toxic to nerve cells.

BPN14770, under development by Tetra Therapeutics, could help activate these mechanisms that support nerve health and prevent dementia, even with the progression of Alzheimer’s.

“Such observations imply that Alzheimer’s pathology can be tolerated by the brain to some extent due to compensatory mechanisms operating at the cellular and synaptic levels,” said study researcher Ying Xu, Associate Professor at University at Buffalo.

Drug, Memory Loss, Nerve Damage
Researchers have discovered a new drug which may protect against memory loss, nerve damage and other symptoms of Alzheimer’s disease. Pixabay

“Our new research suggests that BPN14770 may be capable of activating multiple biological mechanisms that protect the brain from memory deficits, neuronal damage and biochemical impairments,” Xu added.

The research conducted in mice, discovered that BPN14770 inhibits the activity of phosphodiesterase?4D (PDE4D), an enzyme that plays a key role in memory formation, learning, neuroinflammation and traumatic brain injury.

PDE4D lowers cyclic adenosine monophosphate (cAMP) — a messenger molecule that signals physiological changes such as cell division, change, migration and death — in the body, leading to physical alterations in the brain.

cAMP has numerous beneficial functions, including improved memory. By inhibiting PDE4D, BPN14770 increases cAMP signalling in the brain, which ultimately protects against the toxic effects of amyloid beta.

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“The role of PDE4D in modulating brain pathways involved in memory formation and cognition, and the ability of our PDE4D inhibitor to selectively enhance this process, has been well studied,” said Mark E. Gurney from Tetra Therapeutics.

“We are very excited by our colleagues’ findings, which now suggest a second protective mechanism of action for BPN14770 against the progressive neurological damage associated with Alzheimer’s disease,” Gurney said.

“Developing effective drugs for memory deficits associated with Alzheimer’s disease has been challenging,” said M. O’Donnell, Professor at University at Buffalo.

“BPN14770 works by a novel mechanism to increase cyclic AMP signalling in the brain, which has been shown to improve memory. The collaborative project has led to clinical trials that will begin to test its effectiveness,” O’Donnell said. (IANS)