Researchers have found that consuming more foods with choline during pregnancy may boost metabolism and brain development of babies. Although the role of choline in neurodevelopment has been studied before in rodents, the new research was conducted on pigs, which has more relevance to humans.
Austin Mudd, a doctoral student in the Neuroscience Program at the University of Illinois said,”In pigs from choline-deficient moms, their brains were about 10 percent smaller overall.” And 11 of the 19 regions were significantly smaller in choline-deficient brains, he said. The result was the same in grey and white matter concentration of the piglets.
Conversely, piglets whose mothers consumed sufficient choline during pregnancy had higher concentrations of grey and white matter in the brain’s cortical regions. Grey matter is primarily made up of the neurons themselves, while white matter comprises the material that connects neurons and bridges in different parts of the brain.
For the study, the team gave pregnant sows choline-deficient or choline-sufficient diets through the second half of their pregnancies. After weaning, piglets were fed choline-deficient or choline-sufficient milk replacer for 30 days. Then the month-old piglets were scanned by magnetic resonance imaging (MRI).
The left and right cortex were found to be larger in the choline-sufficient pigs, as a result of the a greater density of grey matter in the brain. As part of the study, some of the pigs from choline-deficient mothers were also given adequate amounts of choline after birth.
The results showed that it is not sufficient for the brain. “Postnatal supplementation cannot correct for prenatal deficiency. It has to occur during development,” explained Ryan Dilger, associate professor at the varsity.
“We know that the structural alteration is there, but it may not manifest in ways we can see until later in life. That’s why it’s important to think about this during gestation because the changes are occurring then,” Mudd noted. The study was published in Current Developments in Nutrition. IANS
Microbes may be helping stir up anxiety and depression in obese people, if results from a new mouse study hold true in humans.
The authors link the effects to how the brain responds to insulin, the hormone that regulates sugar levels in the blood.
The research raises questions about whether changing gut microbes, or changing diet, could help treat these conditions.
Mood, microbes and metabolism
Obesity triggers changes in metabolism — for example, making liver, muscle, fat and other tissues less responsive to insulin. Left untreated, these changes can lead to diabetes.
Obese people also have higher rates of anxiety and depression.
“One could say, ‘Maybe that’s just because they’re obese,’ ” said Harvard Medical School diabetes researcher Ronald Kahn, “but others could say, ‘Maybe there’s a metabolic link.’ ”
“And we asked the question, ‘Maybe the metabolic link is at least partly fueled by the microbiome,’ ” the community of microbes living in a person’s gut, he added.
Those microbes change with diet, and Kahn said different microbes might respond differently to the foods we eat.
To test the theory, Kahn and colleagues fed mice a high-fat diet and studied their behavior as the animals became obese.
They used common tests to gauge anxious and depressed behavior in rodents — for example, how much time the animals spent hiding in a dark box versus exploring a brightly lit area. The more anxious the mouse, the less time it will spend in the light.
Obese mice spent about 25 percent less time in the light than animals on a normal diet, and they scored higher on the other anxiety and depression tests, too.
Return to normal
But those differences disappeared when obese mice were given antibiotics, even though their weight didn’t change much.
“That really says there’s probably something about the microbiome,” Kahn said.
The researchers then tested how the animals’ microbiomes affected mice raised in a sterile environment with no microbes of their own.
Bacteria from obese rodents made these germ-free mice more anxious than microbes from normal mice.
But when germ-free mice got microbes from obese animals that had been given antibiotics, they behaved like normal mice.
To see what parts of the brain might be responsible for the effects, the researchers focused on two regions involved in metabolism and responses to rewards. They found these regions were less responsive to insulin in the obese mice compared with normal-weight animals.
Again, antibiotics returned those responses to normal.
“It was actually quite a surprise,” Kahn said. “Even though we had seen some effects on metabolism in the rest of the body, I was very surprised how dramatic and how clear the effects were also on the brain and on behavior.”
Into the unknown
That doesn’t mean antibiotics are the cure for depression, Kahn warned. The drugs kill good and bad microbes indiscriminately, and taking the medication unnecessarily can contribute to the rising threat of antibiotic resistance.
Also, what happens in mice does not necessarily happen in humans, he added, or it may happen for only some people. So far, there is not much evidence that probiotics help anxious people.
“The difficulty is, both of these things — depression and obesity — are complicated things that have multiple, multiple factors influencing them,” said mental health researcher Gregory Simon at Kaiser Permanente Washington Health Research Institute, who was not part of the study.
Microbes are likely just one factor, along with environment, genetics, social influences and more, Simon added.
But Kahn said his group’s research raised interesting questions about how food affects our behavior.
“I think now we can get some idea that there are a lot of things that are being metabolized by gut bacteria that could affect brain function,” he said.
And he said there might be ways to change brain function by changing those bacteria, by eating helpful microbes or by eating foods that sustain them.