Saturday December 7, 2019

Here’s How Proper Sleep Can Help in Reducing Suicidal Thoughts

The frequency and intensity of disturbing dreams or nightmares, also a factor in insomnia-associated suicide

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Suicidal Thoughts
The sleep aid given to people is most effective in reducing Suicidal Thoughts in patients with the most severe insomnia. Pixabay

 Insomnia is a driver of suicide, and people with severe insomnia may safely benefit from taking a sedative to help address their sleep problems as it reduces their Suicidal Thoughts, a new study suggests.

The study, published in The American Journal of Psychiatry, included 103 participants aged 18 to 65 with major depressive disorder, insomnia and suicidal thoughts.

All participants took an antidepressant for the eight-week duration of the trial and half also took the sedative-hypnotic zolpidem at bedtime.

“While the results do not argue for the routine prescription of hypnotics for mitigating suicidal ideation in all depressed outpatients with insomnia, they suggest that co-presciption of a hypnotic during initiation of an antidepressant may be beneficial in suicidal outpatients, especially in patients with severe insomnia,” said study researchers from Augusta University in the US.

During the study, participants completed regular self-reports of the severity of their insomnia and completed a daily sleep diary during their treatment that included details like how many times they woke up during the night and how long they actually slept.

Researchers also measured distorted thoughts about sleep, like participants thinking they would never again have a good night’s sleep.

The frequency and intensity of disturbing dreams or nightmares, also a factor in insomnia-associated suicide, also were measured.

Patients wore a wrist device to keep up with rest/activity cycles.

Those taking the sleep aid showed both significant immediate and longer-term improvement in their reported insomnia severity.

Suicidal Thoughts
Insomnia is a driver of suicide, and people with severe insomnia may safely benefit from taking a sedative to help address their sleep problems as it reduces their Suicidal Thoughts. Pixabay

While both groups reported significant improvement in their feelings about hopelessness, quality of life, nightmares and dysfunctional beliefs about sleep, as well as related insomnia and suicidality, the group taking the sleep aid had a greater reduction in suicidal thinking.

The sleep aid was most effective in reducing suicidal thoughts in patients with the most severe insomnia.

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There were no deaths or suicide attempts by participants during the course of the study.

Two weeks after the study concluded both study groups — including those not taking the sleep aid — appeared to have maintained progress with reduced depression scores and suicidal thoughts. (IANS)

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New Way To Treat Pancreatic Cancer is Here: Researchers

The Decoded mechanism acts efficiently in other types of cancer resistant to current therapies

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Pancreatic Cancer
Researchers have now harnessed information to efficiently eradicate human Pancreatic Cancer cells in xenografts. Pixabay

Pancreatic Cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed but a new study found that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells.

The study, published in the journal Oncotarget, was conducted with xenografts — transplantations of human pancreatic cancer into immunocompromised mice.

The treatment reduced the number of cancer cells by 90 per cent in the developed tumors a month after being administered.

“In research published in 2017, we discovered a mechanism that causes the self-destruction of human cancer cells during their duplication (mitosis) without affecting normal cells,” said study researcher Malca Cohen-Armon from Tel Aviv University in Israel.

“We have now harnessed this information to efficiently eradicate human pancreatic cancer cells in xenografts. The current results were obtained using a small molecule that evokes this self-destruction mechanism in a variety of human cancer cells,” Cohen-Armon added.

According to the researchers, the mice were treated with a molecule called PJ34, which is permeable in the cell membrane but affects human cancer cells exclusively.

This molecule causes an anomaly during the duplication of human cancer cells, provoking their rapid cell death.
Thus, cell multiplication itself resulted in cell death in the treated cancer cells.

Pancreatic Cancer
Pancreatic Cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed but a new study found that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells. Pixabay

A month after being injected with PJ34 daily for 14 days, the pancreatic cancer cells in the tumuors of the treated mice experienced a relative drop of 90 per cent. In one mouse, the tumuor completely disappeared.

“It is important to note that no adverse effects were observed, and there were no changes in the weight gain of the mice, nor in their behaviour,” Cohen-Armon added.

ALSO READ: Protein Deficiency Ordinary Among Indians: Experts

This mechanism acts efficiently in other types of cancer resistant to current therapies.

The molecule PJ34 is being tested in pre-clinical trials according to FDA regulations before clinical trials begin, the study said. (IANS)